Citations (SAM, SAM-T99, HMMs)
10 20 30 40 50 60
| | | | | |
1 MGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAERMF.TREFSKEPELMPKTPSQKN
2 MGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAERMF.TREFSKEPELMPKTPSQKN
3 MGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAERMF.TREFSKEPELMPKTPSQKN
4 MGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAERMF.TREFSKEPELMPKTPSQKN
5 MGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAERMF.TREFSKEPELMPKTPSQKN
6 MGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAERMF.TREFSKEPELMPKTPSQKN
7 MGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAERMF.TREFSKEPELMPKTPSQKN
8 MGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAERMF.TREFSKEPELMPKTPSQKN
9 MGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAKRMF.TSEFSKEPELMPKTPSQKN
10 MGSTAPGPIHLLELCDQKLMEFICNVDNKDLVWLEEIEEEAERMF.TREFSKEPELMPKTPSQKN
11 MGSTAPGPIHLLELCDQKLMEFICNVDNKDLVWLEEIEEEAERMF.TREFSKEPELMPKTPSQKN
12 MGTTAPGPICLLDLCDQKLLDFVCNVDNKDFMWLKEIEEEAERMF.IREFSNEPELMPKTPSQKN
13 MGTTAPGPICLLDLCDQKLLDFVCNVDNKDFMWLKEIEEEAERMF.IREFSNEPELMPKTPSQKN
14 MGTTAPGPICLLDLCDQKLLDFVCNVDNKDFMWLKEIEEEAERMF.IREFSNEPELMPKTPSQKN
15 MGTTAPGPICLLDLCDQKLLDFVCNVDNKDFMWLKEIEEEAERMF.IREFSNEPELMPKTPSQKN
16 MGTTAQGPIHLLELCDQKLLEFVCNVDNKDMLWLEEIEEEAQRMF.TREFSKEPELMPRTPSQKN
17 MGTTAPGPANLLDLCDQKLLDFVYNVDNKDFMWLKEIEEEAERMF.VREFNNEPELMPKTPSQKN
18 MGTTAPGPANLLDLCDQKLLDFVYNVDNKDFMWLKEIEEEAERMF.VREFNNEPELMPKTPSQKN
19 -MNDAECLSHLLQVCARKTEEFVRTLDSKHMVWLLEIEEEARKMF.SSDFNAEPELMPKTPSQK-
20 -MNDAECLSHLLQVCSRKTEEFVRTLDTKHMVWLLEIEEEARKMF.SSDFNAEPELMPKTPSQK-
21 -MNDAECLSHLLQVCARKTEEFVRTLDSKHMVWLLEIEEEARKMF.SSDFNAEPELMPKTPSQK-
22 -MNDAECLSHLLQVCARKTEEFVRTLDSKHMVWLLEIEEEARKMF.SSDFNAEPELMPKTPSQK-
23 --AVATGLARLPVVCNQRLAELLRQVDDVDLLWLEEIHEEAARMF.GSHYSDQPELMPKTPSQKN
24 --AVATGLARLPVVCNQRLAELLRQVDDVDLLWLEEIHEEAARMF.GSHYSDQPELMPKTPSQKN
25 -MNDAECLSHLLQVCSRKTEEFVRTLDTKHMVWLLEIEEEARKMF.SSDFNAEPELMPKTPSQK-
26 ---------------------------------------------.-------------------
27 -MNDAECLSHLLQVCSRKTEEFVRTLDTKHMVWLLEIEEEARKMF.SSDFNAEPELMPKTPSQK-
28 -MNDAECLSHLLQVCARKTEEFVRTLDSKHMVWLLEIEEEARKMF.SSDFNAEPELMPKTPSQK-
29 -MNDAECLSHLLQVCARKTEEFVRTLDSKHMVWLLEIEEEARKMF.SSDFNAEPELMPKTPSQK-
30 -MNDAECLSHLLQVCARKTEEFVRTLDSKHMVWLLEIEEEARKMF.SSDFNAEPELMPKTPSQK-
31 -MNDAECLSHLLQVCSRKTEEFVRTLDTKHMVWLLEIEEEARKMF.SSDFNAEPELMPKTPSQK-
32 ------------------------------MVWLEEIQQEAYRMF.SSDFSTEPELMPKTPSQKK
33 --DPPLLGLSVFQDGEAKIRHFLSDFESKHMKWLEEILIEAKMHF.GRD---DIPLLPKTPAVKN
34 ---------------------------------------------.-------------------
35 MGTTAPGPICLLDLCDQKLLDFVCNVDNKDFMWLKEIEEEAERMF.IREFSNEPELMPKTPSQKN
36 ---------------------------------------------.-------------------
37 ---------------------------------------------.-------------------
38 ---------------------------------------------.-------------------
39 ---------------------------------------------.-------------------
40 MSSVKSSMQSLREMFVGKTQEFIDEITNVHLVWLDEIQQEASRMF.SSDFNAEPELMPKTPSQKK
41 MSSLPEATRSLMQVFNGKLQDFTNEIDNVHMVWLEEIQQEAYRMF.SSDFSTEPELMPKTPSQKK
42 ---------------------------------------------.-------------------
43 ---------------------------------------------.-------------------
44 ---------------------------------------------.-------------------
45 ---------------------------------------------.-------------------
46 ---------------------------------------------.-------------------
47 ---------------------------------------------.-------------------
48 ---------------------------------------------.-------------------
49 ---------------------------------------------.-------------------
50 ---------------------------------------------.-------------------
51 ---AADGPMRLLEVCGQRLSRFLHDAEHKHLAWLREVEEQGLRMLdSSNFRAEPGLMPKTPSQRR
52 ---------------------------------------------.-------------------
53 ---------------------------------------------.-------------------
54 ---------------------------------------------.-------------------
55 ---------------------------------------------.-------------------
56 ---------------------------------------------.-------------------
57 ---------------------------------------------.-------------------
70 80 90 100 110 120
| | | | | |
1 RRKKRRISY.....VQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSVLRRV
2 RRKKRRISY.....VQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSVLRRV
3 RRKKRRISY.....VQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSVLRRV
4 RRKKRRISY.....VQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSVLRRV
5 RRKKRRISY.....VQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATMVGENGSVLRRV
6 RRKKRRISY.....VQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSVLRRV
7 RRKKRRISY.....VQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSVLRRV
8 RRKKRRISY.....VQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATMVGENGSVLRRV
9 RRKKRRISY.....VQDENRDPIRKRLSRRKSRSSQLSSRRLRSKDSVEKLATMAGENGSVLRRV
10 RQKKRRISY.....VQDENRNPIRKRLSRRLSRSSQLSSRHLRSKGKVEKLATVVGENGSVLRRV
11 RQKKRRISY.....VQDENRNPIRKRLSRRLSRSSQLSSRHLRSKGKVEKLATVVGENGSVLRRV
12 RRKKRRVSN.....IQDENRDPVRKRLSRRKSRSSQVGTRHLRSKPVTIVEENGFPVLQRITRAT
13 RRKKRRVSN.....IQDENRDPVRKRLSRRKSRSSQVGTRHLRSKPVTIVEENGFPVLQRITRAT
14 RRKKRRVSN.....IQDENRDPVRKRLSRRKSRSSQVGTRHLRSKPVTIVEENGFPVLQRITRAT
15 RRKKRRVSN.....IQDENRDPVRKRLSRRKSRSSQVGTRHLRSKPVTIVEENGFPVLQRITRAT
16 RRKKRRISS.....TQDENRDPVRKRLSRRKTRSSQRISRHLRSKDKVEKLATVVGENGSVLQRV
17 RRKKRRVSN.....IQDENRDPVRKRLSRRKSRSSQVGPRHRRSKLGAVVEENGSPVLRRITRAA
18 RRKKRRVSN.....IQDENRDPVRKRLSRRKSRSSQVGPRHRRSKLGAVVEENGSPVLRRITRAA
19 RRRKKRTSI.....VPDENRDPSGRRISRRRSSANWSNSVRRLSIRNQNKTNE-----------D
20 RRRKKRTSI.....LPDENRDPSGRRISRRRSSANWSSSVRRLSVRNQIKAND-----------D
21 RRRKKRTSI.....LPDENRDPSGRRISRRQSNASWSSSVRRLSVRNQNKAND-----------D
22 RRRKKRTSI.....LPDENRDPSGRRISRRQSNASWSSSVRRLSVRNQNKAND-----------D
23 RKRRKRPSA.....LRGESLELGRRRLSRRRTNNLKAVSSKRDSQRLQNKEDTEGLGTEAQELSS
24 RKRRKRPSA.....LRGESLELGRRRLSRRRTNNLKAVSSKRDSQRLQNKEDTEGLGTEAQELSS
25 RRRKKRTSI.....LPDENRDPSGRRISRRRSSANWSSSVRRLSVRNQIKAND-----------D
26 ---------.....---------------------------------------------------
27 RRRKKRTSI.....LPDENRDPSGRRISRRRSSANWSSSVRRLSVRNQNKVND-----------D
28 RRRKKRTSI.....LPDENRDPSGRRISRRQSNASWSSSVRRLSVRNQNKAND-----------D
29 RRRKKRTSI.....VPDENRDPSGRRISRRRSSANWSNSVRRLSIRNQNKTNE-----------D
30 RRRKKRTSI.....VPDENRDPSGRRISRRRSSANWSNSVRRLSIRNQNKTNE-----------D
31 RRRKKRTSI.....LPDENRDPSGRRISRRRSSANWSSSVRRLSVRNQIKAND-----------D
32 SNRRKRVSM.....ELNESRS--KRRFSKGKRSNLRRSSVQLTLNTISELVTPHVPNDSSESLTE
33 RARKGRVVVrk7vpIHEETDDIPAKRSRTSARQSTKRQSTKRQSCMSEFHKDAIKSAALMSPPTA
34 ---------.....---------------------------------------------------
35 RRKKRRVSN.....IQDENRDPVRKRLSRRKSRSSQVGTRHLRSKPVTIVEENGFPVLQRITRAT
36 ---------.....---------------------------------------------------
37 ---------.....---------------------------------------------------
38 ---------.....---------------------------------------------------
39 ---------.....---------------------------------------------------
40 NSRRRRVSV.....GRQEENQSRRSSSVKVLNFITEEESVPGASDVSYATRPKRTTRKDKQTKFE
41 SNRRKRVSM.....ELNESRS--KRRFSKGKRSNLRRSSVQLTLNTISELVTPHVPNDSSESLTE
42 ---------.....---------------------------------------------------
43 ---------.....---------------------------------------------------
44 ---------.....---------------------------------------------------
45 ---------.....---------------------------------------------------
46 ---------.....---------------------------------------------------
47 ---------.....---------------------------------------------------
48 ---------.....---------------------------------------------------
49 ---------.....---------------------------------------------------
50 ---------.....---------------------------------------------------
51 RPRKRQSSA.....LKDENEPTRRRWVS-------------------------------------
52 ---------.....---------------------------------------------------
53 ---------.....---------------------------------------------------
54 ---------.....---------------------------------------------------
55 ---------.....---------------------------------------------------
56 ---------.....---------------------------------------------------
57 ---------.....---------------------------------------------------
130 140 150 160 170 180 19
| | | | | |
1 TRAAAAAAAATMALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVTQLMST
2 TRAAAAAAAATMALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVTQLMST
3 TRAAAAAAAATMALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVTQLMST
4 TRAAAAAAAATMALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVTQLMST
5 TRAAAAAAAATMALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVTQLMST
6 TRAAAAAAAATMALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVTQLMST
7 TRAAAAAAAATMALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVTQLMST
8 TRAAAAAAAATMALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVTQLMST
9 TRAAAAAAAATMALAAPSSSTPESPTMLTEKPKDNRAQCQLVPVVEIGIRERHNAEQHVTQLVSV
10 TRAAAAAAAAATAVLATPSPSPESSPALTKKPKNSLAQGQLVPVVEIGVPERKSAEQHLGQLKSV
11 TRAAAAAAAAATAVLATPSPSPESSPALTKKPKNSLAQGQLVPVVEIGVPERKSAEQHLGQLKSV
12 AAAAAAAAAASVASASSSSTA------------GSPTVLTKKAVVEISTSERLSAELQLTKLKGS
13 AAAAAAAAAASVASASSSSTA------------GSPTVLTKKAVVEISTSERLSAELQLTKLKGS
14 AAAAAAAAAASVASASSSSTA------------GSPTVLTKKAVVEISTSERLSAELQLTKLKGS
15 AAAAAAAAAASVASASSSSTA------------GSPTVLTKKAVVEISTSERLSAELQLTKLKGS
16 TRAAAAAAAASVATAPPSP-TCRSPTVLTKNPKESPTQCQLVPAVEIGASERRSAEQHLNHLQSA
17 AAAAAAAASTSASVASASSSPTTVSPI----------VLIKKAVVEVSTGEQLSAELQLIKLKGG
18 AAAAAAAASTSASVASASSSPTTVSPI----------VLIKKAVVEVSTGEQLSAELQLIKLKGG
19 SMQEEPAQPKRMTRARAQASIMCPSVVEMALPESPSQLYQKNVQVTISEQDRRSAEQKLVGSATE
20 SIQEGPAQPKRMTRARAQASIMCPPAVEQALPESPSQLCQKSVQVKISEHERRSAEQKLRESEIE
21 SIQEEPAQLKRMTRARAQASIKSTPVLETALPESPSQICQKNAQVKISEQERRSAEQKLIESDFE
22 SIQEEPAQLKRMTRARAQASIKSTPVLEKALPESPSQICQKNAQVKISEQECRSAEQKLIESDFE
23 QTVSRRLTRSQVAAPADRSEVL-----------PEHLRERVVPVVEISVCDRISAEFQFQKCASE
24 QTVSRRLTRSQVAAPADRSEVL-----------PEHLRERVVPVVEISVCDRISAEFQFQKCASE
25 SIQEEPAQPKRMTRARAQASIMCPPAVEQALPESPSQLCQKIVQVKIGEHERRSAEQKLRESDKK
26 -----------------------------------------------------------------
27 SIQENPAQPKRMTRARAQASIMCLPAVEQALPESPSQLCQKSVQVKISEHERRSAEQKLRESDIE
28 SIQEEPAQLKRMTRARAQASIKSTPVLETALPESPSQICQKNAQVKISEQERRSAEQKLIESDFE
29 SMQEEPAQPKRMTRARAQASIMCPSVVEMALPESPSQLYQKNVQVTISEQDRRSAEQKLVGSATE
30 SMQEEPAQPKRMTRARAQASIICPSVVEMALPESPSQLYQKNVQVTISEQDRRSAEQKLVGSATE
31 SIQEGPAQPKRMTRARAQASIMCPPAVEQALPESPSQLCQKSVQVKISEHERRSAEQKLRESEIE
32 EPARRTRRNKTAAPAEPEP--IKRSTRNKAATKAEEEVVEEVPEVKQACEDSTSNKDQLLVSAAV
33 TPPRKKVKEEILSPVNAAVETTSAPSPPSVTAKEEVVDPEVVALAEVSPPAKQSRATRASNVAVE
34 -----------------------------------------------------------------
35 AAAAAAAAAASVASASSSSTA------------GSPTVLTKKAVVEISTSERLSAELQLTKLKGS
36 -----------------------------------------------------------------
37 -----------------------------------------------------------------
38 -----------------------------------------------------------------
39 -----------------------------------------------------------------
40 ETEDASHAPETAENKKPEPAALQEMDEKSTADDGEDKPGQPVPQLPAPEVATSVSSAHQFLSEKP
41 EPARRTRRNKTAAPAEPEP--IKRSTRNKAATKAEEEVVEEVPEVKQACEDSTSNKDQLLVSAAV
42 -----------------------------------------------------------------
43 -----------------------------------------------------------------
44 -----------------------------------------------------------------
45 -----------------------------------------------------------------
46 -----------------------------------------------------------------
47 -----------------------------------------------------------------
48 -----------------------------------------------------------------
49 -----------------------------------------------------------------
50 -----------------------------------------------------------------
51 -----------------------------------------------------------------
52 -----------------------------------------------------------------
53 -----------------------------------------------------------------
54 -----------------------------------------------------------------
55 -----------------------------------------------------------------
56 -----------------------------------------------------------------
57 -----------------------------------------------------------------
0 200 210 220 230 240 25
| | | | | |
1 EP.LPRTLSPTPASATAPTSQGIPTSDEESTPKKSKARILE....SITVSSLMATPQDPKGQGVG
2 EP.LPRTLSPTPASATAPTSQGIPTSDEESTPKKSKARILE....SITVSSLMATPQDPKGQGVG
3 EP.LPRTLSPTPASATAPTSQGIPTSDEESTPKKSKARILE....SITVSSLMATPQDPKGQGVG
4 EP.LPRTLSPTPASATAPTSQGIPTSDEESTPKKSKARILE....SITVSSLMATPQDPKGQGVG
5 EP.LPRTLSPTPASATAPTSQGIPTSDEESTPKKSKARILE....SITVSSLMATPQDPKGQGVG
6 EP.LPRTLSPTPASATAPTSQGIPTSDEESTPKKSKARILE....SITVSSLMATPQDPKGQGVG
7 EP.LPRTLSPTPASATAPTSQGIPTSDEESTPKKSKARILE....SITVSSLMATPQDPKGQGVG
8 EP.LPRTLSPTPASATAPTSQGIPTSDEESTPKKSKARILE....SITVSSLMATPQDPKGQGVG
9 QP.LPRTLSPTLASATAPASQGILTSDEESTPKKSKARILE....SVTVSSLMATPQDPKGRGVG
10 QT.PLAPSPP----ATTPASHSILLSEEDSTPKKPEAGRPE....TITVSSLMATPQDPKGRGVG
11 QT.PLAPSPP----ATTPASHSILLSEEDSTPKKPEAGRPE....TITVSSLMATPQDPKGRGVG
12 LP.------------PSPVSQGTLTSEEELTPKKSEAGKLD....SVTVNSLKATPQSPKNRGVG
13 LP.------------PSPVSQGTLTSEEELTPKKSEAGKLD....SVTVNSLKATPQSPKNRGVG
14 LP.------------PSPVSQGTLTSEEELTPKKSEAGKLD....SVTVNSLKATPQSPKNRGVG
15 LP.------------PSPVSQGTLTSEEELTPKKSEAGKLD....SVTVNSLKATPQSPKNRGVG
16 QA.--------PTSTLAPASHIPSSSDEDSTPQKAEAGRLE....SVTVSSLMTTPRDPKGRGAG
17 LP.QSS----VPAPATSSVSQGTLTSEEEATPKKSEAGRLDsatdSVAVNSLKATPQSPKNRGVG
18 LP.QSS----VPAPATSSVSQGTLTSEEEATPKKSEAGRLDsatdSVAVNSLKATPQSPKNRGVG
19 ESeMKTDVLPVPKIAKDTISEIVNTVVPPPVPE--------....-TPAVPVTPENKSRAAAKLK
20 DSeMKTDVQPIPEITKDHISEIMNAAGPPPIPD--------....-IPAVPVTPENKSRAAGKLK
21 LK.TV----------------------PEITKDNVSETVNS....AVPAVPVTPENKSRAAGKLK
22 LK.TV----------------------PEITKDNVSETVNS....AVPAVPVTPENKSRAAGKLK
23 RA.ENHSASLPPSSDDKSPKESSAAESQPLPAASELIVPHT....PEAKGAGKNKSAFKKTANVA
24 RA.ENHSASLPPSSDDKSPKESSAAESQPLPAASELIVPHT....PEAKGAGKNKSAFKKTANVA
25 DSeMKTDVQPIPEITKGRISEIMTAAGPPPVPD--------....-IPAVPVTPENKSRAAGKLK
26 --.--------------------------------------....--------------------
27 DSeMKTDVQPIPEITKGRISEIMNAAGPPPVPD--------....-IPAVPVTPENKSRAAGKLK
28 LK.TV----------------------PEITKDNVSETVNS....AVPAVPVTPENKSRAAGKLK
29 ESeMKTDVLPVPKIAKDTISEIVNTVVPPPVPE--------....-TPAVPVTPENKSRAAAKLK
30 ESeMKTDVLPVPKIAKDTISEIVNTVVPPPVPE--------....-TPAVPVTPENKSRAAAKLK
31 DSeMKTDVQPIPEITKDHISEIMNAAGPPPIPD--------....-IPAVPVTPENKSRAAGKLK
32 VK.IPSS---------------------------------E....RLSAESLLNSGQSPGRSANK
33 TT.SAPSSPTVIVKEEVVEPEIIAPAEASPPAKRSRATRAS....TRASTARTAAKQGPKTRITA
34 --.------------------------QQSISLNTKLRRPS....NFEGDIVLNKKRESASKRKK
35 LP.------------PSPVSQGTLTSEEELTPKKSEAGKLD....SVTVNSLKATPQSPKNRGVG
36 --.--------------------------------------....--------------------
37 --.--------------------------------------....--------------------
38 --.--------------------------------------....--------------------
39 --.--------------------------------------....--------------------
40 AP.EVTVSISSADRLSAEKARSPEGSPGRTATKVAIANGAQ....NARRSSVALKLRHSVAGLRH
41 VK.IPSS---------------------------------E....RLSAESLLNSGQSPGRSANK
42 --.--------------------------------------....--------------------
43 --.--------------------------------------....--------------------
44 --.--------------------------------------....--------------------
45 --.--------------------------------------....--------------------
46 --.--------------------------------------....--------------------
47 --.--------------------------------------....--------------------
48 --.--------------------------------------....--------------------
49 --.--------------------------------------....--------------------
50 --.--------------------------------------....--------------------
51 --.--------------------------------------....--------------------
52 --.--------------------------------------....--------------------
53 --.--------------------------------------....--------------------
54 --.--------------------------------------....--------------------
55 --.--------------------------------------....--------------------
56 --.--------------------------------------....--------------------
57 --.--------------------------------------....--------------------
0 260 270 280 290 300 310
| | | | | | |
1 TGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDSQSVRHSPIAP.SSP
2 TGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDSQSVRHSPIAP.SSP
3 TGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDSQSVRHSPIAP.SSP
4 TGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDSQSVRHSPIAP.SSP
5 TGRSVSKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSHMDSQSVRHSPIAP.SSP
6 TGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDSQSVRHSPIAP.SSP
7 TGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDSQSVRHSPIAP.SSP
8 TGRSVSKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSHMDSQSVRHSPIAP.SSP
9 TGRSVSKLRIARVSPGPRDSPGSPDSPWRERVLAPILPNNFSMPTGSPADSQSVRHSLVAP.SSL
10 TSRSASKLRMVQASPGPQDLPGSLASPWPGRVLTSILPDNCSTPTGTHVDQQSVWHSLIAP.SSP
11 TSRSASKLRMVQASPGPQDLPGSLASPWPGRVLTSILPDNCSTPTGTHVDQQSVWHSLIAP.SSP
12 EGRSVSKLKIARASWGLQDSPGSTDSPWQERVLSPILLNNILPTTAKSPLGNIRSVRRSLI.SQD
13 EGRSVSKLKIARASWGLQDSPGSTDSPWQERVLSPILLNNILPTTAKSPLGNIRSVRRSLI.SQD
14 EGRSVSKLKIARASWGLQDSPGSTDSPWQERVLSPILLNNILPTTAKSPLGNIRSVRRSLI.SQD
15 EGRSVSKLKIARASWGLQDSPGSTDSPWQERVLSPILLNNILPTTAKSPLGNIRSVRRSLI.SQD
16 AGRSASKLRIAAAAPGPQDSPSSPASPWRERVLAPLQPDNFSTPVGARVDRQSVRRSLIAP.SSP
17 EARSVSKLKIARASRGLQDSPGSTDSPWQERVLSPILPNNILSTTAKNPLGSIQSVQQSLI.SQD
18 EARSVSKLKIARASRGLQDSPGSTDSPWQERVLSPILPNNILSTTAKNPLGSIQSVQQSLI.SQD
19 IAGSSTPIEAAEMVDLTCESPRPANELANEQPLN--LTNQSVTPTGSKSDRRSVRRSLVVVkPSS
20 ISGSSTPIQTAAVVDLTCESPRPANELVNEQPLN--LSNESATPTGSKSDRRSVRRSLVVRkSSS
21 IAASSTPEQKAEMVDLTCESPRPANE------QQLNLSNQSATPTGSKSDRRSVRRSLVVRkSSS
22 IAASSTPEQKAEMVDLTCESPRPANE------QQLNLSNQSATPTGSKSDRRSVRRSLVVRkSSS
23 DTTVVLSEKELGLEEVDDSAQVQKHNERDDKEPSQRTTDSPETPTGSRLSRRSVRRSLMGK.PST
24 DTTVVLSEKELGLEEVDDSTQVQKHNERDDKEPSQRTTDSPETPTGSRLSRRSVRRSLMGK.PST
25 ISGSSTPIQTAAVVDLTCESPQPANELVNEQPLN--LSNQSATPTGSKSDRRSVRRSLVVRkSSS
26 -------------------------------------------------------------.---
27 ISGSSTPIQTAAVVDLTCESPQPANELVNEQPLN--LSNQSATPTGSKSDRRSVRRSLVVRkSSS
28 IAASSTPEQKAEMVDLTCESPRPANE------QQLNLSNQSATPTGSKSDRRSVRRSLVVRkSSS
29 IAGSSTPIEAAEMVDLTCESPRPANELANEQPLN--LTNQSVTPTGSKSDRRSVRRSLVVVkPSS
30 IAGSSTPIEAAEMVDLTCESPRPANELANEQPLN--LTNQSVTPTGSKSDRRSVRRSLVVVkPSS
31 ISGSSTPIQTAAVVDLTCESPRPANELVNEQPLN--LSNESATPTGSKSDRRSVRRSLVVRkSSS
32 IPIAASGLQ---------------------------------------------NTPQGSS.RTS
33 TKGRGSKKKSSTEAQTSQEESATSAKETEATVKVEKAAPPPVKVKPLRASTRGATRTATST.RQS
34 SARSSSDEDTSQGPTKHSKTEEKNETLLKKITNVNSQNHSPVIAHTIEQEKNELSSSIRTR.SSS
35 EGRSVSKLKIARASWGLQDSPGSTDSPWQERVLSPILLNNILPTTAKSPLGNIRSVRRSLI.SQD
36 -------------------------------------------------------------.---
37 -------------------------------------------------------------.---
38 -----------------------------------FQDSNDEMTTVISKTRRSGRRSYVGGtHKG
39 -------------------------------------------------------------.---
40 SLTQESVRRASRRSMLKRKAARATNSQCNSNEALNEMA-----------------------.---
41 IPIAASGLQ---------------------------------------------NTPQGSS.RTS
42 -------------------------------------------------------------.---
43 -------------------------------------------------------------.---
44 -------------------------------------------------------------.---
45 ------------------------------------------------------DATFEVH.SND
46 ------------------------------------------------------DATFEVH.SND
47 -------------------------------------------------------------.---
48 -------------------------------------------------------------.---
49 -------------------------------------------------------------.---
50 -------------------------------------------------------------.---
51 -------------------------------------------------------------.---
52 -------------------------------------------------------------.---
53 -------------------------------------------------------------.---
54 -------------------------------------------------------------.---
55 -------------------------------------------------------------.---
56 -------------------------------------------------------------.---
57 -------------------------------------------------------------.---
320 330 340 350 360
| | | | |
1 .SPQ.VLAQKYSLVAKQESVVRRASRRLAKKTA...EEPAASGR.IICHS.....YLERLLNVEV
2 .SPQ.VLAQKYSLVAKQESVVRRASRRLAKKTA...EEPAASGR.IICHS.....YLERLLNVEV
3 .SPQ.VLAQKYSLVAKQESVVRRASRRLAKKTA...EEPAASGR.IICHS.....YLERLLNVEV
4 .SPQ.VLAQKYSLVAKQESVVRRASRRLAKKTA...EEPAASGR.IICHS.....YLERLLNVEV
5 .SPQ.VLAQKYSLVAKQESVVRRASRRLAKKTA...EEPAASGR.IICHS.....YLERLLNVEV
6 .SPQ.VLAQKYSLVAKQESVVRRASRRLAKKTA...EEPAASGR.IICHS.....YLERLLNVEV
7 .SPQ.VLAQKYSLVAKQESVVRRASRRLAKKTA...EEPAASGR.IICHS.....YLERLLNVEV
8 .SPQ.VLAQKYSLVAKQESVVRRASRRLAKKTA...EEPAASGR.IICHS.....YLERLLNVEV
9 .SPQ.VLAQKYSLVAKEESVVRRASRRLAKKTA...EEPAASGR.IICHS.....YLERLLNVEV
10 gCQV.SLAQECSLVAKQEKPVRRSSRRIGKKAT...EEPAASAR.IICHS.....YLERLLNVEV
11 gCQV.SLAQECSLVAKQEKPVRRSSRRIGKKAT...EEPAASAR.IICHS.....YLERLLNVEV
12 .SQV.PLASKYNLVAKQENGSRRSSRRIAKKAG...KEPEASAR.IICHS.....YLERLLNVEV
13 .SQV.PLASKYNLVAKQENGSRRSSRRIAKKAG...KEPEASAR.IICHS.....YLERLLNVEV
14 .SQV.PLASKYNLVAKQENGSRRSSRRIAKKAG...KEPEASAR.IICHS.....YLERLLNVEV
15 .SQV.PLASKYNLVAKQENGSRRSSRRIAKKAG...KEPEASAR.IICHS.....YLERLLNVEV
16 .GPQaSLAQNRSPVSKEESTVRRSSRRIARKAA...KEPTASAR.IICHS.....YLERLLNVEV
17 .SQV.PLAKKYCLVTQQENASRRSS-RIAKKAG...KEPEASAR.IICHS.....YLERLLNVEV
18 .SQV.PLAKKYCLVTQQENASRRSS-RIAKKAG...KEPEASAR.IICHS.....YLERLLNVEV
19 .RRS.SLASQFSLASKRESMTREAVRKSIRQSI...AKKKAAME.TSSASsq6cqSSIEIIDDEI
20 .RRA.SLVSQFSLVSKRESMTREAVRKSIRQSI...SKKKAAME.TSSTSsq6chSSIEMVDDEI
21 .RRA.SLASQFSLASKRESMTREAVRKSIRQSI...SQKKAAME.ISSTSsq6yqSSIEMVDDEI
22 .RRA.SLASQFSLASKRESMTREAVRKSIRQSI...SQKKAAME.ISSTSsq6yqSSIEMVDDEI
23 .IRRtSLAEKYSLARKRESTIRKSIARTVIKRK...APQKLSVS.SSSVN.....G---------
24 .IRRtSLAEKYSLARKRESTIRKSIARTVIKRK...APQKLSVS.SSSVN.....G---------
25 .RRA.SLVSQFSLVSKRESMTREAVRKSIRQSI...SKKKAAME.TSSTSsq6chSSIEMVDDEI
26 .---.----------------------------...--------.-----.....----------
27 .RRA.SLVSQFSLVSKRESMTREAVRKSIRQSI...SKKKAAME.TSSTSsq6chSSIEMVDDEI
28 .RRA.SLASQFSLASKRESMTREAVRKSIRQSI...SQKKAAME.ISSTSsq6yqSSIEMVDDEI
29 .RRS.SLASQFSLASKRESMTREAVRKSIRQSI...AKKKAAME.TSSASsq6cqSSIEIIDDEI
30 .RRS.SLASQFSLASKRESMTREAVRKSIRQSI...AKKKAAME.TSSASsq6cqSSIEIIDDEI
31 .RRA.SLVSQFSLVSKRESMTREAVRKSIRQSI...SKKKATME.TSSTSsq6chSSIEMVDDEI
32 .ARR.SLVVRRSLVGLRHSMTQEAVRRASRRSF...LKKKARLGnSTCSS.....SVSEDICMDV
33 .TRS.RLVQNVSQSPASSPHVRAEAPGSVRGKR...LCSKLART.PQTPSt110aFFSSLTCRAV
34 .RKR.TFSQSENMKNKKSNNIDDTLIAPITNDI...DEPSMYED.AIG--.....--KPTPIMNS
35 .SQV.PLASKYNLVAKQENGSRRSSRRIAKKAG...KEPEASAR.IICHS.....YLERLLNVEV
36 .---.----------------------------...--------.-----.....----------
37 .---.----------------------------...--------.-----.....----------
38 .HKT.SLAEKYSLASKRESMIRRSISRAIAKKAaaqESSSASSR.VSCQS.....SLEVFVEEDV
39 .---.----------------------------...--------.-----.....----------
40 .---.----------------------------...--------.-----.....----------
41 .ARR.SLVVRRSLVGLRHSMTQEAVRRASRRSF...LKKKARLGnSTCSS.....SVSEDICMDV
42 .---.----------------------------...--------.-----.....----------
43 .---.----------------------------...--------.-----.....----------
44 .---.----------------------------...--------.-----.....----------
45 .KKQ.PLSKQDSLLTEDESVEEKLPTTKLLSSI...KAIKL--P.TRTHE.....LFNPLLQSPV
46 .KKQ.PLSKQDSLLTEDESVEEKLPTTKLLSSI...KAIKL--P.TRTHE.....LFNPLLQSPV
47 .---.----------------------------...--------.-----.....----------
48 .---.----------------------------...--------.-----.....----------
49 .---.----------------------------...--------.-----.....----------
50 .---.----------------------------...--------.-----.....----------
51 .---.----------------------------...--------.-----.....----------
52 .---.----------------------------...--------.-----.....----------
53 .---.----------------------------...--------.-----.....----------
54 .---.----------------------------...--------.-----.....----------
55 .---.----------------------------...--------.-----.....----------
56 .---.----------------------------...--------.-----.....----------
57 .---.----------------------------...--------.-----.....----------
370 380 390 400 410 420 430
| | | | | | |
1 PQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEA
2 PQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEA
3 PQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEA
4 PQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEA
5 PQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEA
6 PQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEA
7 PQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEA
8 PQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEA
9 PEKVGPEQESPEEAEP-VAAAEPEVPENNGNNSWPRNDTEIGNSTPNPKPAASSPETPSAGQQEA
10 PQKVGEEAEPVEAAEPEVRQASQGVSKDDRSTLCSRSATKIAISTPGSRPLAGGQETPSEGQQEP
11 PQKVGEEAEPVEAAEPEVRQASQGVSKDDRSTLCSRSATKIAISTPGSRPLAGGQETPSEGQQEP
12 PQNVGLEQEPVEVAEPEEAEEEQEVSKNSGCPSKPRSATKIAISTPTSKPAAASQTTTVE-EQEA
13 PQNVGLEQEPVEVAEPEEAEEEQEVSKNSGCPSKPRSATKIAISTPTSKPAAAGQTTTVE-EQEA
14 PQNVGLEQEPVEVAEPEEAEEEQEVSKNSGCPSKPRSATKIAISTPTSKPAAAGQTTTVE-EQEA
15 PQNVGLEQEPVEVAEPEEAEEEQEVSKNSGCPSKPRSATKIAISTPTSKPAAAGQTTTVE-EQEA
16 PQKVSPKEEEPSKEAEPEEAAEPEVPKNNGGALQLRSTTNITLSPPSSQPAASSQ-GECEGWQEA
17 PQNVGLEKEPVEVAEPEEAVEEQEVSKNSGCSSKPHSATKMAISTPTSKPVATGQATAVE-EQDA
18 PQNVGLEKEPVEVAEPEEAVEEQEVSKNSGCSSKPHSATKMAISTPTSKPVATGQATAVE-EQDA
19 TIKIRPETAPSESVSEEAHTIESPR---RSLRSRTFKKIAISNLPDSEEPQRRVTRQMVAMDAEP
20 TIKIRPETAPSETVSEEAPAAESPRSSL---RSRAFKKIAISNLSESEEPPRRVTRQMVAVDAEP
21 TIKIRPETVPSETVSEEAPAAESPR---RSLRSRAFKKIAISNLPDSEEPPRKVTRQMVAGNAEP
22 TIKIRPETVPSETVSEEAPAAESPR---RSLRSRAFKKIAISNLPDSEEPPRKVTRQMVAGNAEP
23 ---------SGSEEVPEDEETVVNAGPPPVPQTPPKLDFQGLRMSLRSQTVNRNEQQQETSNNEC
24 ---------SGSEEVPEDEETVVNAGPPPVPQTPPKLDFQGLRMSLRSQTVNRNEQQQETSNNEC
25 TIKIRPETAPSETVSEEAPAAESPRSSL---RSRAFKKIAISNLSESKEPPRRVTRQMVAVDAEP
26 -------------------------------------------------------------FTEA
27 TIKIRPETAPSETVSEEAPAAESPRSSL---RSRAFKKIAISNLSESKEPPRRVTRQMVAVDAEP
28 TIKIRPETVPSETVSEEAPAAESPR---RSLRSRAFKKIAISNLPDSEEPPRKVTRQMVAGNAEP
29 TIKIRPETAPSESVSEEAHTIESPR---RSLRSRTFKKIAISNLPDSEEPQRRVTRQMVAMDAEP
30 TIKIRPETAPSESVSEEAHTIESPR---RSLRSRTFKKIAISNLPDSEEPQRRVTRQMVAMDAEP
31 TIKIRPETAPSETVSEEAPAAESPRSSL---RSRAFKKIAISNLSESKEPPRRVTRQMVAVDAEP
32 EPEPEDMDNREEKVDAEPATETRPEPEIIQPQEPEPEKMEEKEIELTEEKLPEVIIESPSTTENC
33 EANPPAETLKPETSEASQSEQEKATVSDAPTKATIKNDHRSDDDDDEADPVAAADDTALSQDSLE
34 TMNFNSTFTTQKIMNATVVLEPLSAVKLNETVTIKKTSDNNIRNSNEQKAVEMKTEFRTTFKVPS
35 PQNVGLEQEPVEVAEPEEAEEEQEVSKNSGCPSKPRSATKIAISTPTSK----------------
36 -----------------------------------------------------------------
37 -----------------------------------------------------------------
38 TNNLRTGLE--------------------------------------------------------
39 -----------------------------------------------------------------
40 -----------------------------------------------------------------
41 EPEPED-----------------------------------------------------------
42 -----------------------------------------------------------------
43 -----------------------------------------------------------------
44 -----------------------------------------------------------------
45 KMRVEAF--------------ENAANAQNSMRPKRGKDLQGTPGSNNTPKIGKLPAPTVGRFFTP
46 KMRVEAF--------------ENAANAQNSMRPKRGKDLQGTPGSNNTPKIGKLPAPTVGRFFTP
47 -----------------------------------------------------------------
48 -----------------------------------------------------------------
49 -----------------------------------------------------------------
50 -----------------------------------------------------------------
51 -----------------------------------------------------------------
52 -----------------------------------------------------------------
53 -----------------------------------------------------------------
54 -----------------------------------------------------------------
55 -----------------------------------------------------------------
56 -----------------------------------------------------------------
57 -----------------------------------------------------------------
440 450 460 470 480 490
| | | | | |
1 KTDQADGPREPPQS.....ARRKRSYKQAVSELDEEQ.HLEDEELQPPRSKTPSSPCPASKVVRP
2 KTDQADGPREPPQS.....ARRKRSYKQAVSELDEEQ.HLEDEELQPPRSKTPSSPCPASKVVRP
3 KTDQADGPREPPQS.....ARRKRSYKQAVSELDEEQ.HLEDEELQPPRSKTPSSPCPASKVVRP
4 KTDQADGPREPPQS.....ARRKRSYKQAVSELDEEQ.HLEDEELQPPRSKTPSSPCPASKVVRP
5 KTDQADGPREPPQS.....ARRKRSYKQAVSELDEEQ.HLEDEELQPPRSKTPSSPCPASKVVRP
6 KTDQADGPREPPQS.....ARRKRSYKQAVSELDEEQ.HLEDEELQPPRSKTPSSPCPASKVVRP
7 KTDQADGPREPPQS.....ARRKRSYKQAVSELDEEQ.HLEDEELQPPRSKTPSSPCPASKVVRP
8 KTDQADGPREPPQS.....ARRKRSYKQAVSELDEEQ.HLEDEELQPPRSKTPSSPCPASKVVRP
9 KTDQADGPREPPQS.....ARRKRSYKQAVSELDEEQ.HLEDEELQPPRSKTPSSPCPSSKVVRP
10 KTDQGDSPKEPPQS.....VRRKRSYKQAVSELDDEQ.QLEDEELQAPRSKTPSPPCPASKVVRP
11 KTDQGDSPKEPPQS.....VRRKRSYKQAVSELDDEQ.QLEDEELQAPRSKTPSPPCPASKVVRP
12 ELDQTDGHREPPQS.....VRRKRSYKQAISEP-DEE.QLEDEELQPFQNKTPSPPCPANKVVRP
13 ELDQTDGHREPPQS.....VRRKRSYKQAISEP-DEE.QLEDEELQPCQNKTPSPPCPANKVVRP
14 ELDQTDGHREPPQS.....VRRKRSYKQAISEP-DEE.QLEDEELQPCQNKTPSPPCPANKVVRP
15 ELDQIDGHREPPQS.....VRRKRSYKQAISEP-DEE.QLEDEELQPCQNKTPSPPCPANKVVRP
16 ETDQADGPKEPPQS.....VRRKRSYKQAVNELDEEQ.QLEDEELQPPRSKTPSPPCPSSKVVRP
17 ELDQTDGHREPPQS.....VRRKRSYKQAMSEL-DEE.HLEDEELQPPRNKTPSPPCPASKVVRP
18 ELDQTDGHREPPQS.....VRRKRSYKQAMSEL-DEE.HLEDEELQPPRNKTPSPPCPASKVVRP
19 TPETTDDAQN----.....-IRRKSYKRAVDELSDDE.RPSEGERSPPRKKTPSPPCPPSKIVKP
20 TPETADDAQN----.....-NRRKSYKRAVDELSDDE.RPSEGECSPPRKKTPSPPCPPSKIVKP
21 TPETTEDAQN----.....-IRRKSYKRAVDELSDDE.RPSEEERSPPRKKTPSPPCPPSKIVRP
22 TPETTEDAQN----.....-IRRKSYKRAVDELSDDE.RPSEEERSPPRKKTPSPPCPPSKIVRP
23 DLSKSEKTQEPPQS.....ARRKTSYKRAVDQRYDTQ.QAEDGGLSPLRKKTPSPPCPASKVVRP
24 DLSKSEKTQEPPQS.....ARRKTSYKRAVDQRYDTQ.QAEDGGLSPLRKKTPSPPCPASKVVRP
25 TPETADDAQN----.....-NRRKSYKRAVDELSDDE.RPSEGECSPPRKKTPSPPCPPSKIVKP
26 KTDQADGPREPPQSar6sgKGRKRSYKQAVSELDEEQ.HLEDEELQPPRSKTPSSPCPASKVVRP
27 TPETADDAQN----.....-NRRKSYKRAVDELSDDE.RPSEGECSPPRKKTPSPPCPPSKIVKP
28 TPETTEDAQN----.....-IRRKSYKRAVDELSDDE.RPSEEERSPPRKKTPSPPCPPSKIVRP
29 TPETTDDAQN----.....-IRRKSYKRAVDELSDDE.RPSEGERSPPRKKTPSPPCPPSKIVKP
30 TPETTDDAQN----.....-IRRKSYKRAVDELSDDE.RPSEGERSPPRKKTPSPPCPPSKIVKP
31 TPETADDAQN----.....-NRRKSYKRAVDELSDDE.RPSEGECSPPRKKTPSPPCPPSKIVKP
32 RLTRSKARTSVTDD.....SGGSKSIGDGRSTRSGSKrRAGESEMSTPKKKNTPPKKCLTSIAPH
33 ESPESQDETDSQSSt105qADEKNTSSSSTGSSSSSY.GSSGCESDDIIDKTPSPECPPSKVIRP
34 SPSPSSMALQYRMQ.....QLKQAMVNKEFDELLTED.ESSPEVKKPKANIKNDDGIPNTPAKPT
35 --------------.....------------------.---------------------------
36 -----------EQM.....SITRKAVAQSSSLSRNAA.YSGTPRRNPPREAHGNHGTPRNIFPST
37 --------------.....------------------.-------------------------PH
38 --------------.....------------------.---------------------------
39 --------------.....--SKKKTE--GSISRNAA.YSGTPRRNPPREAHNQ-ATPRNIFSST
40 --------------.....------------------.---------------------------
41 --------------.....------------------.---------------------------
42 --------------.....------------------.---------------------------
43 --------------.....------------------.---------------------------
44 --------------.....------------------.---------------------------
45 TQTTSTLPLSSAQP.....KKGPASASKATSLLKTAT.GTN------------------------
46 TQTTSTLPLSSAQP.....KKGPASASKATSLLKTAT.GTN------------------------
47 --------------.....------------------.---------------------------
48 --------------.....------------------.---------------------------
49 --------------.....------------------.---------------------------
50 --------------.....------------------.---------------------------
51 --------------.....------------------.---------------------------
52 --------------.....------------------.---------------------------
53 --------------.....------------------.---------------------------
54 --------------.....------------------.---------------------------
55 --------------.....------------------.---------------------------
56 --------------.....------------------.---------------------------
57 --------------.....------------------.---------------------------
500 510 520 530 540
| | | | |
1 ....LRTFLHTVQRNQMLMT..P.TS.APRSVMKSFIKRN.TPLRMDPKCSFVEK.....E.RQR
2 ....LRTFLHTVQRNQMLMT..P.TS.APRSVMKSFIKRN.TPLRMDPKCSFVEK.....E.RQR
3 ....LRTFLHTVQRNQMLMT..P.TS.APRSVMKSFIKRN.TPLRMDPKCSFVEK.....E.RQR
4 ....LRTFLHTVQRNQMLMT..P.TS.APRSVMKSFIKRN.TPLRMDPK----EK.....E.RQR
5 ....LRTFLHTVQRNQMLMT..P.TS.APRSVMKSFIKRN.TPLRMDPKCSFVEK.....E.RQR
6 ....LRTFLHTVQRNQMLMT..P.TS.APRSVMKSFIKRN.TPLRMDPKCSFVEK.....E.RQR
7 ....LRTFLHTVQRNQMLMT..P.TS.APRSVMKSFIKRN.TPLRMDPK----EK.....E.RQR
8 ....LRTFLHTVQRNQMLMT..P.TS.APRSVMKSFIKRN.TPLRMDPK----EK.....E.RQR
9 ....LRTFLHTVQRNQMLMT..P.TS.APRSVMKSFIKRN.TPLRVDPKCSFVEK.....E.RQR
10 ....LRTFLHTVQRNQMLMT..P.TSaPRGSVMKSFIKRN.TPLRVDPKCSFVEK.....E.RQR
11 ....LRTFLHTVQRNQMLMT..P.TSaPRGSVMKSFIKRN.TPLRVDPK----EK.....E.RQR
12 ....LRTFLHTVQKNQMLMT..P.TLaSRSSVMKSFIKRN.TPLRVDPK----EK.....E.RQR
13 ....LRTFLHTVQKNQMLMT..P.TLaSRSSVMKSFIKRN.TPLRVDPKCSFVEK.....E.RQR
14 ....LRTFLHTVQKNQMLMT..P.TLaSRSSVMKSFIKRN.TPLRVDPK----EK.....E.RQR
15 ....LRTFLHTVQKNQMLMT..P.TLaSRSSVMKSFIKRN.TPLRVDPK----EK.....E.RQR
16 ....LRTFLHTVQRNQMLMT..PtST.PHGNIMKSFIKRN.TPLRVDPKSSFVEK.....E.RQR
17 ....LRTFLHTVQKNQMLMT..P.TLaSRSSVMKSFIKRN.TPLRVDPK----EK.....E.RQR
18 ....LRTFLHTVQKNQMLMT..P.TLaSRSSVMKSFIKRN.TPLRVDPK----EK.....E.RQR
19 pph.MKSFLHTVQKNQLLMMtpG.SI.GKNIMMKSFIKRN.TPLKMDPK----EK.....E.RQR
20 pph.MKSFLHTVQKNQFLMMtpG.SI.GKNITLKSFIKRN.TPLKPDPKSE--EK.....E.RQR
21 pph.MKSFLHTVQKNQLLMMtpG.SI.GKNIIMKSFIKRN.TPLKTDPKTE--EK.....E.RQR
22 pph.MKSFLHTVQKNQLLMMtpG.SI.GKNIIMKSFIKRN.TPLKTDPKTE--EK.....E.RQR
23 ....FKTFLHTVEKNQLLMT..PsSV.GRNGVIKSFIKYN.TPLQHDPK----EK.....E.RQK
24 ....FKTFLHTVQKNQLLMT..PsSV.GRNGVIKSFIKYN.TPLQHDPK----EK.....E.RQK
25 pph.MKSFLHTVQKNQFLMMtpG.SI.GKNITLKSFIKRN.TPLKPDPKSE--EK.....E.RQR
26 ....LRTFLHTVQRNQMLMT..P.TS.APRSVMKSFIKRN.TPLRMDPK----EK.....E.RQR
27 pph.MKSFLHTVQKNQFLMMtpG.SI.GKNITLKSFIKRN.TPLKPDPKSE--EK.....E.RQR
28 pph.MKSFLHTVQKNQLLMMtpG.SI.GKNIIMKSFIKRN.TPLKTDPK----EK.....E.RQR
29 pph.MKSFLHTVQKNQLLMMtpG.SI.GKNIMMKSFIKRN.TPLKMDPKTE--EK.....E.RQR
30 pph.MKSFLHTVQKNQLLMMtpG.SI.GKNIMMKSFIKRN.TPLKMDPK----EK.....E.RQR
31 pph.MKSFLHTVQKNQFLMMtpG.SI.GKNITLKSFIKRN.TPLKPDPKSE--EK.....E.RQR
32 ....MRSFVHTVQKNQILMMtpG.SL.GRSTIMKSFIKQSaTKPDVKLGSGSVER.....E.RQK
33 hpksFLNVLNANKKKKLVCP..G.TP.QSGSVVTSFIQRN.TPQKRTFK----EQ.....Q.QER
34 ....LKEINTIINTGFQEMR..N.TY.KSNALFSPYAKES.VKKRVEAFEQVGMN.....S.PKP
35 ....----------------..-.--.-------------.--------------.....-.---
36 ....PGK--GIATPSRVVAP..P.RT.PHRAIPFSEAEKN.PDQKLKHADELRNKa12kaE.ENR
37 ....MRSFLHAVQKNQVLMMtpN.TL.GRSGVIKSFIKHT.TPLRIDPK----TK.....E.RHK
38 ....----------------..-.--.-----------LN.TPNE-------KEK.....E.RQR
39 ....PGRMAG--TPGRAAVV..P.RT.PHRVIPFNDAEKD.PNARMKHADELRMK.....ElEKK
40 ....----------------..-.--.-------------.--------------.....-.---
41 ....----------------..-.--.-------------.--------------.....-.---
42 ....----------------..-.--.-------------.--------------.....-.---
43 ....----------------..-.--.------------T.TSL-----------.....-.---
44 ....----------------..-.--.-------------.--------------.....-.---
45 ....LRSVNSTSTK------..-.--.-------------.--------------.....-.---
46 ....LRSVNSTSTK------..-.--.-------------.--------------.....-.---
47 ....----------------..-.--.-------------.--------------.....-.---
48 ....----------------..-.--.-------------.--------------.....-.---
49 ....----------------..-.--.-------------.--------------.....-.---
50 ....----------------..-.--.-------------.--------------.....-.---
51 ....----------------..-.--.-------------.--------------.....-.---
52 ....----------------..-.--.-------------.--------------.....-.---
53 ....----------------..-.--.-------------.--------------.....-.---
54 ....----------------..-.--.-------------.--------------.....-.---
55 ....----------------..-.--.-------------.--------------.....-.---
56 ....----------------..-.--.-------------.--------------.....-.---
57 ....----------------..-.--.-------------.--------------.....-.---
550 560 570 580 590
| | | | |
1 LENLRRKEEAEQLRRQKVEEDKRRRLEEVK.....LKREERLRKVLQARERVE.....QMKE.EK
2 LENLRRKEEAEQLRRQKVEEDKRRRLEEVK.....LKREERLRKVLQARERVE.....QMKE.EK
3 LENLRRKEEAEQLRRQKVEEDKRRRLEEVK.....LKREERLRKVLQARERVE.....QMKE.EK
4 LENLRRKEEAEQLRRQKVEEDKRRRLEEVK.....LKREERLRKVLQARERVE.....QMKE.EK
5 LENLRRKEEAEQLRRQKVEEDKRRRLEEVK.....LKREERLRKVLQARERVE.....QMKE.EK
6 LENLRRKEEAEQLRRQKVEEDKRRRLEEVK.....LKREERLRKVLQARERVE.....QMKE.EK
7 LENLRRKEEAEQLRRQKVEEDKRRRLEEVK.....LKREERLRKVLQARERVE.....QMKE.EK
8 LENLRRKEEAEQLRRQKVEEDKRRRLEEVK.....LKREERLRKVLQARERVE.....QMKE.EK
9 LENLRRKEEAEQLRRQKVEEDKRRRLEEVK.....LKREERLRKVLQARERVE.....QMKE.EK
10 LENLRRKEEAELLRRQKVEEDKRRRLEEVK.....LKREERLRKVLQARERVE.....QMKE.EK
11 LENLRRKEEAELLRRQKVEEDKRRRLEEVK.....LKREERLRKVLQARERVE.....QMKE.EK
12 LESLRRKEEAEQRRRQKVEEDKRRRLEEVK.....LKREERLRKVLQARERVE.....QMKE.EK
13 LESLRRKEEAEQRRRQKVEEDKRRRLEEVK.....LKREERLRKVLQARERVE.....QMKE.EK
14 LESLRRKEEAEQRRRQKVEEDKRRRLEEVK.....LKREERLRKVLQARERVE.....QMKE.EK
15 LESLRRKEEAEQRRRQKVEEDKRRRLEEVK.....LKREERLRKVLQARERVE.....QMKE.EK
16 LENLRRKEEAEQLRRQKVEEDKRRRLEEVK.....LKREERLRKVLQARERVE.....QMKE.EK
17 LESLRRKEEAEQLRRQKVEEDKRRRLEEVK.....LKREERLRKVLQARERVE.....QMKE.EK
18 LESLRRKEEAEQLRRQKVEEDKRRRLEEVK.....LKREERLRKVLQARERVE.....QMKE.EK
19 LDALRKKEEAELQRKQKIEEGKKRKQEELK.....LRREERLRKVLQARERVE.....QLEE.EK
20 LDALRKKEEAELQRKQKIEEGKKRKQEELK.....LRREDRLRKVLQARERVE.....QLEE.EK
21 LDALRKKEEAELQRKQKIEEGKKRKQEELK.....VRREERLRKVLQARERVE.....QLEE.EK
22 LDALRKKEEAELQRKQKIEEGKKRKQEELK.....VRREERLRKVLQARERVE.....QLEE.EK
23 LQALRKKEEAEQLRKQKVEEEKKRRQEEAK.....LRREERLRKVLQARERAE.....QLEE.ER
24 LQALRKKEEAEQLRKQKVEEEKKRRQEEAK.....LRREERLRKVLQARERAE.....QLEE.ER
25 LDALRKKEEAELQRKQKIEEGKKRKQEELK.....LRREDRLRKVLQARERVE.....QLEE.EK
26 LENLRRKEEAEQLRRQKVEEDKRRRLEEVK.....LKREERLRKVLQARERVE.....QMKE.EK
27 LDALRKKEEAELQRKQKIEEGKKRKQEELK.....LRREDRLRKVLQARERVE.....QLEE.EK
28 LDALRKKEEAELQRKQKIEEGKKRKQEELK.....VRREERLRKVLQARERVE.....QLEE.EK
29 LDALRKKEEAELQRKQKIEEGKKRKQEELK.....LRREERLRKVLQARERVE.....QL--.--
30 LDALRKKEEAELQRKQKIEEGKKRKQEELK.....LRREERLRKVLQARERVE.....QLEE.KK
31 LDALRKKEEAELQRKQK-------------.....------------------.....----.--
32 WDALNKKIEQENERKKKIEEERRKKQEEMK.....KKRDERLKRVVEARVKSE.....KEKEqEK
33 KALLLEKQKKEENIKKKMIEDRRKQLQDQK.....RTREDRMRRAKETRALQE.....EEKK.ER
34 VVDIDIPTRITRTKTRARAAAQAEALENMN.....IAEKTVAHKLARKSLAKA.....KKIS.LA
35 ------------------------------.....------------------.....----.--
36 AAVLQRKQELDRIRMEKLDGIKKKDERVAT.....FQKNMKDHHKSPTRTRVNp10mkQSAR.KV
37 LEALKKKQEQEEERMKKMEEEKKRKQEELKr27rcRKRDERLKRVFEAKVKEE.....QREE.EK
38 LESLRKKQEAEEQRKKKVEEEKRRRQAEMK.....QKREERLRKALQARERVE.....QMEE.EK
39 REKARKDEEKRNAVMERRKEQERVRQEKLD.....QLKQKEERNANLAKLHNS.....AKSP.TR
40 ------------------------------.....------------------.....----.--
41 ------------------------------.....------------------.....----.--
42 ------------------------------.....------------------.....----.--
43 ------------------------------.....------------------.....----.--
44 ------------------------------.....------------------.....----.--
45 ------------------------------.....------------------.....----.--
46 ------------------------------.....------------------.....----.--
47 ------------------------------.....------------------.....----.--
48 ------------------------------.....------------------.....----.--
49 ------------------------------.....------------------.....----.--
50 ------------------------------.....------------------.....----.--
51 ------------------------------.....------------------.....----.--
52 ------------------------------.....------------------.....----.--
53 ------------------------------.....------------------.....----.--
54 ------------------------------.....------------------.....----.--
55 ------------------------------.....------------------.....----.--
56 ------------------------------.....------------------.....----.--
57 ------------------------------.....------------------.....----.--
600 610 620 630 640 650
| | | | | |
1 KKQIEQKFAQIDEKTE.....KAKEERLAEEKAKKKAAAKKMEEVEARRKQEEDARRLRWLQQEE
2 KKQIEQKFAQIDEKTE.....KAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEE
3 KKQIEQKFAQIDEKTE.....KAKEERLAEEKAKKKAAAKKMEEVEARRKQEEDARRLRWLQQEE
4 KKQIEQKFAQIDEKTE.....KAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEE
5 KKQIEQKFAQIDEKTE.....KAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEE
6 KKQIEQKFAQIDEKTE.....KAKEERLAEEKAKKKAAAKKMEEVEARRKQEEDARRLRWLQQEE
7 KKQIEQKFAQIDEKTE.....KAKEERLAEEKAKKKAAAKKMEEVEARRKQEEDARRLRWLQQEE
8 KKQIEQKFAQIDEKTE.....KAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEE
9 KKQIEQKFAQIDEKTE.....KAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEE
10 KKQIEQKFAQIDEKTE.....KAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEVRRLRRLQQDE
11 KKQIEQKFAQIDEKTE.....KAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEVRRLRRLQQDE
12 KKQIEQKFAQIDEKTE.....KAKEERLA-EKAKKKATAKKMEEVEARRKQEEEARRLRWLQQEE
13 KKQIEQKFAQIDEKTE.....KAKEERLA-EKAKKKATAKKMEEVEARRKQEEEARRLRWLQQEE
14 KKQIEQKFAQIDEKTE.....KAKEERLA-EKAKKKATAKKMEEVEARRKQEEEARRLRWLQQEE
15 KKQIEQKFAQIDEKTE.....KAKEERLA-EKAKKKATAKKMEEVEARRKQEEEARRLRWLQQEE
16 KKQIEQKFAQIDEKTE.....KAKEERLAEEKARKKAAAKKMEEVEARRKQEEEARRLKWLQQEE
17 KKQIEQKFAQIDEKTE.....KAKEERLA-EKAKKKAAAKKMEEMEARRKQEEEARRLKWLQQEE
18 KKQIEQKFAQIDEKTE.....KAKEERLA-EKAKKKAAAKKMEEMEARRKQEEEARRLKWLQQEE
19 KKKIEQKFAQIDEKSE.....KVREDRMAEEKAKKKITAKKQEEVECRRRQEEEARKLKAKQMEE
20 KKKFEQKFAQIDEKSE.....KVREDRMAEEKAKKKTMVKKQEEVECRRKQEEEARKLKAKQMEE
21 KKKIEQKFAQIDEKSE.....KVREDRMAEEKAKKKMTAKKQEEVECRRKQEEEARRLKVKQMEE
22 KKKIEQKFAQIDEKSE.....KVREDRMAEEKAKKKMTAKKQEEVECRRKQEEEARRLKVKQMEE
23 KRRIEQKLALFDEKTE.....KAREERLAEEKIKKRAAAKKMEEAEARRRQDEEARKQKALQQEE
24 KRRIEQKLALFDEKTE.....KAREERLAEEKIKKRAAAKKMEEAEARRRQDEEARKQKALQQEE
25 KKKFEQKFAQIDEKSE.....KVREDRMAEEKAKKKTMVKK------------------------
26 KKQIEQKFAQIDEKTE.....KAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEE
27 KKKFEQKFAQIDEKSE.....KVREDRMAEEKAKK------------------------------
28 KKKIEQKFAQIDEKSE.....KVREDRMAEEKAKK------------------------------
29 ----------------.....--------------------------------------------
30 KKKK------------.....--------------------------------------------
31 ----------------.....--------------------------------------------
32 KKKIEEKMAQLEKKND.....LLRVERMAEEKAKRKVATKRQEELELRRKQEEAARQKKQQQVEE
33 NQKMQEREEHKQTLTE.....KQKEERKKDEEQRGKIYEKKKAEAEERRKQEMESKLRKIKEQEE
34 KQNKDVDEHKENKLQS.....AQKIKIISMEKINYKQQQKATPLTKTKTQLPLSVNRIPHTPSNQ
35 ----------------.....--------------------------------------------
36 FPTTSDAATPGRGPAK.....KGRIEVFGAEKEGVTVAQATVQISPSRDPLRNSNRQVKGEQMES
37 KKKVEQKMAQIEEKNEh12ltRFCLQRLAEEKAKKKAAAKRQEELEQKKKMEEEARKKKL----E
38 KKRMEQKILQSDEKVRls...QVREEKVSEERSKKKL---------SKKPWESDVRKQKILKLEE
39 ARLMQDHAPNKAASRK.....IFPTAESTSTPGRGPAKKGKVEILIGSDGQKTAPVAQPTVELSP
40 ----------------.....--------------------------------------------
41 ----------------.....--------------------------------------------
42 ----------------.....---------------------------------AMDEKKKKREE
43 ----------------.....---------------------------------AMDEKKKKREE
44 ----------------.....--------------------------------------------
45 ----------------.....--------------------------------------TLSREN
46 ----------------.....--------------------------------------TLSREN
47 ----------------.....--------------------------------------------
48 ----------------.....--------------------------------------------
49 ----------------.....--------------------------------------------
50 ----------------.....--------------------------------------------
51 ----------------.....--------------------------------------------
52 ----------------.....--------------------------------------------
53 ----------------.....--------------------------------------------
54 ----------------.....--------------------------------------------
55 ----------------.....--------------------------------------------
56 ----------------.....--------------------------------------------
57 ----------------.....--------------------------------------------
660 670 680 690 700 710
| | | | | |
1 EERRH.QELLQKKKE.EEQERLRKAAEAKRLAEQREQERR..EQERREQERREQ.....ERREQE
2 EERRH.QELLQKKKE.EEQERLRKAAEAKRLAEQREQERR..EQERREQERREQ.....E-----
3 EERRH.QELLQKKKE.EEQERLRKAAEAKRLAEQREQERR..EQERREQERREQ.....E-----
4 EERRH.QELLQKKKE.EEQERLRKAAEAKRLAEQREQERR..EQERREQERREQ.....E-----
5 EERRH.QELLQKKKE.EEQERLRKAAEAKRLAEQREQERR..EQERREQ-----.....-----E
6 EERRH.QELLQKKKE.EEQERLRKAAEAKRLAEQREQERR..EQERREQERREQ.....ERREQE
7 EERRH.QELLQKKKE.EEQERLRKAAEAKRLAEQREQERR..EQERREQERREQ.....ERREQE
8 EERRH.QELLQKKKE.EEQERLRKAAEAKRLAEQREQERR..EQERREQ-----.....-----E
9 EERRH.QELLQKKKE.EEQERLRKAAEAKRLAEQR-----..------------.....------
10 EERRH.QELLQKKKE.EEQERLRKVAEAKRLAEQREQERQ..LAEQREQERRKE.....QERLQA
11 EERRH.QELLQKKKE.EEQERLRKVAEAKRLAEQREQERQ..LAEQREQERRKE.....QERLQA
12 EERRH.QEMLQRKKE.EEQERRKAAEARRLAEQREQERRR..EQERREQERREQ.....ERREQE
13 EERRH.QEMLQRKKE.EEQERRKAAEARRLAEQREQERRR..EQERREQERREQ.....ERREQE
14 EERRH.QEMLQRKKE.EEQERRKAAEARRLAEQREQERRR..EQERREQERREQ.....ERREQE
15 EERRH.QEMLQRKKE.EEQERRKAAEARRLAEQREQERRR..EQERREQERREQ.....ERREQE
16 EERRH.QELLQKRRE.EEQERLRKAAEARRLAEQREQERQ..LAEQREQERKRE.....Q-----
17 EERRH.QEMLQRKKE.EEQERRKAAEARRLAEQREQERRR..EQERREQERREQ.....ERREQE
18 EERRH.QEMLQRKKE.EEQERRKAAEARRLAEQREQERRR..EQERREQERREQ.....ERREQE
19 EERRH.QDLLQKKREeEELERQKKIAEAKRLAEQRQAEQE..RERQREQQLLAE.....KERLRA
20 EERRH.QELLQKKREeEEMERQKKMAEAKRL---------..AEQERERQVFAE.....KERLRA
21 EERRH.QELLQKKREeEELERQKKIAEAKRL---------..AEQERERQLLAE.....KERLRA
22 EERRH.QELLQKKREeEELERQKKIAEAKRL---------..AEQERERQLLAE.....KERLRA
23 EERRH.KELMQKKKE.EEQERARKIAEQRQAEQEREKQLA..AEREQERKKEQE.....RKKEEE
24 EERRH.KELMQKKKE.EEQERARKIAEQRQAEQEREKQLA..AEREQERKKEQE.....RKKEEE
25 -----.---------.------------------------..------------.....------
26 EERRH.QELLQKKKE.EEQERLRKAAEAKRLAEQREQERR..EQERREQERREQ.....E-----
27 -----.---------.------------------------..------------.....------
28 -----.---------.------------------------..------------.....------
29 -----.---------.------------------------..------------.....------
30 -----.---------.------------------------..------------.....------
31 -----.---------.------------------------..------------.....------
32 EERRF.QEMQAKRKA.EEEREKARKLAEATRALELKKEQE..REREREREREREre9erERERQA
33 EKRRH.QHLMDRRREhEEQERQRRAEEQRQQAEQLRLKQE..RLRLEEIMKKKE.....QTLIRE
34 INTNN.NKPLSAVRS.NIITSVESLIQAPKSVNKPKEKQD..MEKRQKAEKERE.....EKARLA
35 -----.---------.------------------------..------------.....------
36 EGIVPvKQPKPRLKA.KRSQPTHTVPSSSKSTAEDDGAAV..LKAEQEQYLIKQ.....AADAKV
37 EEKRQ.QELLAKKKA.EEEEQARKLAEARRALELKREQER..ERERQ------L.....ERERLA
38 DKLEQ.QELLQKRRE.AEGEEKGKVLELKDLVEQRQVEQV..KERDLKQWGKEK.....ALHSQI
39 SRELQ.RNGSRQVKM.EPMSCDDSTPPARQHKPKAKATKRsaHAASSSTSNVEA.....AAALAA
40 -----.---------.------------------------..------------.....------
41 -----.---------.------------------------..------------.....------
42 KQRLA.QQQREQIEK.EKRENAERLMKEKEEKHRKLVQEK..EDKLRADLVKKA.....KKMEEF
43 KQRLA.QQQREQIEK.EKRENAERLMKEKEEKHRKLVQEK..EDKLRADLVKKA.....KKMEEF
44 -----.-SALKASHA.EYREIEMRRHEKEQEALKKREAML..QAQSEEKRRKRE.....EKQLKA
45 SGDDF.RKGL-----.------------------------..------------.....------
46 SGDDF.RKGL-----.------------------------..------------.....------
47 -----.---------.------------------------..------------.....------
48 -----.---------.------------------------..------------.....------
49 -----.---------.------------------------..------------.....------
50 -----.---------.------------------------..------------.....------
51 -----.---------.------------------------..------------.....------
52 -----.---------.------------------------..------------.....------
53 -----.---------.------------------------..------------.....------
54 -----.---------.------------------------..------------.....------
55 -----.---------.------------------------..------------.....------
56 -----.---------.------------------------..------------.....------
57 -----.---------.------------------------..------------.....------
720 730 740 750 760 770
| | | | | |
1 RREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQ
2 RREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQ
3 RREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQ
4 RREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQ
5 RREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQ
6 RREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQ
7 RREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQ
8 RREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQ
9 --EQERREQERQLAEQERRREQERLQAERELQEREKALRLQKERLQRELEEKKKKEEQQRLAERQ
10 EREQQE-------------------------REREKALQLQKERLQRELEEKKKKEEQERLREER
11 EREQQE-------------------------REREKALQLQKERLQRELEEKKKKEEQERLREER
12 RREQERREQEQE-----------RLRAKREMQEREKALRLQKERLQKELEEKKRKEEQQRLAEQQ
13 RKEQERREQEQE-----------RLRAKREMQEREKALRLQKERLQKELEEKKRKEEQQRLAEQQ
14 RKEQERREQEQE-----------RLRAKREMQEREKALRLQKERLQKELEEKKRKEEQQRLAEQQ
15 RKEQERREQEQE-----------RLRAKREMQEREKALRLQKERLQKELEEKKRKEEQQRLAEQQ
16 ----------------------ERLQAERELQEREKALRLQKERLQRELEEKKRKEEQQRLAEQR
17 RREQERREQERR---EQERREQERLRAKREMQEREKALRLQKERLQRELEEKKKKEEQQRLAEQQ
18 RREQERREQERR---EQERREQERLRAKREMQEREKALRLQKERLQRELEEKKKKEEQQRLAEQQ
19 --ERERIEREKALQLQRELERAAQEKEQQRREAEERKKREQQERLEQERLERLHKEQEAKRLQEE
20 ERERERIEREKALQLQRELERAAQEKEQQRREAEERKKREQQQRLEQERLERLRTEQEVKRLQEE
21 EREKERIEKEKALQLQRELERAAQEKEQQRREAEERKKREQQERLEQERL---RKEQEAKRLQEE
22 EREKERIEKEKALQLQRELERAAQEKEQQRREAEERKKREQQERLEQERL---RKEQETKRLQEE
23 RIQAEKQREQQEKAARLQKEVLAAKEQLQKEMEKKEKEEQLLAEMKRQEQEQKKLPEEQK-----
24 RIQAEKQREQQEKAARLQKEVLAAKEQLQKEMEKKE-----------------------------
25 -----------------------------------------------------------------
26 RREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQ
27 -----------------------------------------------------------------
28 -----------------------------------------------------------------
29 -----------------------------------------------------------------
30 -----------------------------------------------------------------
31 -----------------------------------------------------------------
32 IAEKERLEKEKAIALQKELERAAREKERREIEEKRKMEEQRRAEQEREAQLKHAAAAASTATAQV
33 KEQQKLKEERERERKEQDRRRQQEAEQRERERKAKEEAERQRKIAAERALREKQRKEEETHIKGI
34 QQLQEKQREEMEKKRLAQLQRAQEKEERRKQEEQLRLQRLQEQEEAERILAEQRRREQEAERRKE
35 -----------------------------------------------------------------
36 RAEEQRFLQEKTAAELRARAEEQRLQQEKKAAEEKAEARRKRAEEEKSRLLEAQREEEERLRKQQ
37 AAERERVEKEKALALQRELQRAAREKERRELEEKRKLLEEKRRQVGRLRGGSKKVVVTQEEAQRL
38 ESMVFTDKNTKKEDGLQEPR-------------------------------------------QQ
39 LQEQQRIQLEQEQYLLQLAEDERRKREQKEMKEKAEKERQLRAREEQEHFLAVQREEQAQLEKQR
40 -----------------------------------------------------------------
41 -----------------------------------------------------------------
42 EKRRHLEELNQKLLAEQKREELAKLEQQQRTEREQAELFKINQAKENYEIKLHKQMYQQKMQQQQ
43 EKRRHLEELNQKLLAEQKREELAKLEQQQRTEREQAELFKINQAKENYEIKLHKQMYQQKMQQQQ
44 QQQREMIEKEKQKALEAQRLKEERHRQH--IAEQEEKKLKLKEELEKKRLIVKNRAIEQKKYEEE
45 -------HNLAEERKKLREQKHQQAAQQREAKERERAERMAKLAAERAKKQEERKRIEERKRQEL
46 -------HNLAEERKKLREQKHQQAAQQREAKERERAERMAKLAAERAKKQEERKRIEERKRQEL
47 ------------ERKKLREQKHQQAAQQREAKERERAERMAKLAAERAKKQEERKRIEERKRQEL
48 ------KEKIREDNERKASEVLERKKALEEQKMKQKSSSRHGASLKRTETLAGGQGPNKKTRVHL
49 ----QLLPQAGSEKQDLKKKLDKRLSEVMRNQQEQQLLRRRQEQQKRKSQLEDGKKHRPRIFSEI
50 ------------KLHTAKKENRGSDSQGSKMAHANELRSKLLLLKKEKLREDNERKASEVLGEEK
51 -----------------------------------------------------------------
52 -----------------------------------------------------------------
53 -----------------------------------------------------------------
54 -----------------------------------------------------------------
55 -----------------------------------------------------------------
56 -----------------------------------------------------------------
57 -----------------------------------------------------------------
780 790 800 810 820 830
| | | | | |
1 LQEEQEKKAKEAAGASKALNVTVDVQSPACT.....SYQMTPQ.GHR..APPKINPDNYGM..D.
2 LQEEQEKKAKEAAGASKALNVTVDVQSPACT.....SYQMTPQ.GHR..APPKINPDNYGM..D.
3 LQEEQEKKAKEAAGASKALNVTVDVQSPACT.....SYQMTPQ.GHR..APPKINPDNYGM..D.
4 LQEEQEKKAKEAAGASKALNVTVDVQSPACT.....SYQMTPQ.GHR..APPKINPDNYGM..D.
5 LQEEQEKKAKEAAGASKALNVTVDVQSPACT.....SYQMTPQ.GHR..APPKINPDNYGM..D.
6 LQEEQEKKAKEAAGASKALNVTVDVQSPACT.....SYQMTPQ.GHR..APPKINPDNYGM..D.
7 LQEEQEKKAKEAAGASKALNVTVDVQSPACT.....SSPITPQ.GHK..APPQINPHNYGM..D.
8 LQEEQEKKAKEAAGASKALNVTVDVQSPACT.....SYQMTPQ.GHR..APPKINPDNYGM..D.
9 LQEEQEKKAKEAAGVSKALNVTVDVQSPACT.....SYQMTPQ.GRR..APPKINPDNYGM..D.
10 LAEEQQRKAKEVAVTGKGLNVTVDVQSPACT.....SYQMTPQ.GHR..APPKINPDNYGM..D.
11 LAEEQQRKAKEVAVTGKGLNVTVDVQSPACT.....SYQMTPQ.GHR..APPKINPDNYGM..D.
12 LQEEQAKKAKEVAAARKVLNMTVDVQSPVCT.....SYQMTPQ.GPK..SIPKISVDDYGM..D.
13 LQEEQAKKAKEVAAARKVLNMTVDVQSPVCT.....SYQMTPQ.GPK..SIPKISVDDYGM..D.
14 LQEEQAKKAKEVAAARKVLNMTVDVQSPVCT.....SYQMTPQ.GPK..SIPKISVDDYGM..D.
15 LQEEQAKKAKEVAAARKVLNMTVDVQSPVCT.....SYQMTPQ.GPK..SIPKISVDDYGM..D.
16 LQEEQEKKAKEAAAASNSLNVTVDVQSPACT.....SYQMTPQ.GHR..APPKINADDYGM..D.
17 LQEEQAKKAKEVA-AGKALNMTVDVQSPVCT.....SYQMTPQ.GPK..SFPKISMDDYGM..D.
18 LQEEQAKKAKEVA-AGKALNMTVDVQSPVCT.....SYQMTPQ.GPK..SFPKISMDDYGM..D.
19 QQRKAKEQAA-AASAPVMNVTVDMQNSPACE.....SYEMTPK.SYKa.PSVKVNEENYGM..D.
20 QQRKAKEQAAAAAAP-VMNVTVDMQNSPACE.....SYEMTPK.SYKv.PSVKANADNYGM..D.
21 EQRKAKEQAAVAASAPVMNVTVDMQNSPACE.....SYEMTPK.SCKv.PSVKVNEDNYGM..D.
22 EQRKAKEQAAVAASAPVMNVTVDMQNSPACE.....SYEMTPK.SCKv.PSVKVNEDNYGM..D.
23 -----------AKDVAQTQHLENKENSPACN.....SYQMTPQ.YHKdpKPPKINPNNYGM..D.
24 -------------------------NSPACN.....SYQMTPQ.YHKdpKPPKINPNNYGM..D.
25 -------------------------------.....-------.---..------------..-.
26 LQEEQEKKAKEAAGASKALNVTVDVQSPACT.....SYQMTPQ.GHR..APPKINPDNYGM..D.
27 -------------------------------.....-------.---..------------..-.
28 -------------------------------.....-------.---..------------..-.
29 -------------------------------.....-------.---..------------..-.
30 -------------------------------.....-------.---..------------..-.
31 -------------------------------.....-------.---..------------..-.
32 TKTAANILNTTITKSTALNMTVDIENSVLKTp29pqSYQITPK.GQK..ITVLVNPEDYGM..D.
33 MEKEKAKQQEHERLKANILKQNTSLNQQHNT.....SVTHNST.FQQ..GQVESSPQSYDL..Y.
34 AELRTQQQAAIEAMKAK--------------.....-NQMLAQ.TKY..GSKYNGPTTYIL..Ds
35 -------------------------------.....-------.---..------------..-.
36 AREDAELQATLAKQAEKKAKLEAQGKEPPST.....AYQMTPP.RTY..Q--ANSKNDYGLn.D.
37 AAEQRAAKEREAAAKQREAAAKQVNPVVVVEp84pqSYVITPKgGNK..PVFSKSAEDYGM..D.
38 LAEEKKTEQPECFSAASSTWLSKTVKKSIST.....SCLAPPK.GTK..E--SRSPNNYGM..D.
39 EREEAELQATLARCAEKQARQEALRKTPPPA.....AYEMTPP.RTY..Q--NNSKNDYGLn.D.
40 -------------------------------.....-------.---..------------..-.
41 -------------------------------.....-------.---..------------..-.
42 KLQQAQV-----------------LQQQQLQ.....LKKLKQN.GTV..ATLEKNLFTFDM..I.
43 KLQQAQV-----------------LQQQQLQ.....LKKLKQN.GTV..ATLEKNLFTFDM..I.
44 QKREEERKAAELAAK-----LAKQDEDITKM.....LQKQKER.KAP..IYMREPAPPLPS..D.
45 EELQRKMRQQEEAEALKKAKFKELEQQKLQQ.....LTGAKPK.KML..PPPPKTKYTWEM..L.
46 EELQRKMRQQEEAEALKKAKFKELEQQKLQQ.....LTGAKPK.KML..PPPPKTKYTWEM..L.
47 EELQRKMRQQEEAEALKKAKHKELEQQKLQQ.....LTGAKPK.KML..PPPPKTKYTWEM..L.
48 FPKEDKASVLDTSDVVVLTHSVKKQEIGFTT.....NSNKMTS.HRG..VCRENTTSDYGLd.D.
49 SDNTSAARQKTPANPYLSKLPNQSVLYDLHT.....ADHRANA.EPV..PGLHLINGNYGG..Dt
50 VVGRAENEAKVVFSTWCITHSVKKQKTGFTT.....NLNKMTS.HRG..VCRGNTTSDYGLd.D.
51 -------------------------------.....-------.---..------------..-.
52 ----------------------------PVM.....SYKMTPT.RVH..K--PKSATDYGV..E.
53 -------------------------------.....-------.---..------------..-.
54 -------------------------------.....-------.NTS..VELPEINSDY--..-.
55 -------------------------------.....-------.NTS..VELPEINSDY--..-.
56 -------------------------------.....-------.---..---------YQMsdD.
57 -------------------------------.....-------.---..------------..-.
840 850 860 870
| | | |
1 ..LNSDDS.TDDE.....A..HPRKP.....IPTWARGTPLSQAIIHQY..YHPPNLLELFGTI.
2 ..LNSDDS.TDDE.....A..HPRKP.....IPTWARGTPLSQAIIHQY..YHPPNLLELFGTI.
3 ..LNSDDS.TDDE.....A..HPRKP.....IPTWARGTPLSQAIIHQY..YHPPNLLELFGTI.
4 ..LNSDDS.TDDE.....A..HPRKP.....IPTWARGTPLSQAIIHQY..YHPPNLLELFGTI.
5 ..LNSDDS.TDDE.....A..HPRKP.....IPTWARGTPLSQAIIHQY..YHPPNLLELFGTI.
6 ..LNSDDS.TDDE.....A..HPRKP.....IPTWARGTPLSQAIIHQY..YHPPNLLELFGTI.
7 ..LNSDDS.TDDE.....A..HPRKP.....IPTWARGTPLSQAIIHQY..YQPPNLLELFGTI.
8 ..LNSDDS.TDDE.....A..HPRKP.....IPTWARGTPLSQAIIHQY..YHPPNLLELFGTI.
9 ..LNSDDS.TDDE.....A..HPRKP.....IPNWARGTPLSQAIIHQY..YHPPNLLELFGAI.
10 ..LNSDDS.TDDE.....A..HPRKP.....IPSWARGTQLSQAIIHQY..YHPPNLLELFGTI.
11 ..LNSDDS.TDDE.....A..HPRKP.....IPSWARGTQLSQAIIHQY..YHPPNLLELFGTI.
12 ..LNSDDS.TDDE.....S..HPRKP.....IPSWAKGTQLSQAIVHQY..YHPPNILELFGSI.
13 ..LNSDDS.TDDE.....S..HPRKP.....IPSWAKGTQLSQAIVHQY..YHPPNILELFGSI.
14 ..LNSDDS.TDDE.....S..HPRKP.....IPSWAKGTQLSQAIVHQY..YHPPNILELFGSI.
15 ..LNSDDS.TDDE.....S..HPRKP.....IPSWAKGTQLSQAIVHQY..YHPPNILELFGSI.
16 ..LNSDDS.TDDE.....A..HPRKP.....IPSWARGTQLSQAVIRQY..YQPPDLLDLFGSL.
17 ..LNSDDS.TDDE.....A..HPRKP.....IPSWAKGTQLSQAIVHQY..YHPPNILELFGSI.
18 ..LNSDDS.TDDE.....A..HPRKP.....IPSWAKGTQLSQAIVHQY..YHPPNILELFGSI.
19 ..LNSDDS.TDDE.....S..QPRKP.....IPAWASGNLLAQAIRQQY..YKPMDVDRMYGTI.
20 ..LNSDDS.TDDE.....S..QPRKP.....IPAWASGNLLAQAVSQQY..YKPIDADHMYGTI.
21 ..LNSDDS.TDDE.....S..QPRKP.....IPAWASGNLLTQAIRQQY..YKPIDVDRMYGTI.
22 ..LNSDDS.TDDE.....S..QPRKP.....IPAWASGNLLTQAIRQQY..YKPIDVDRMYGTI.
23 ..LNSDDS.TDDE.....S..QPRKP.....IPAWASGNQLSQAVIRQY..YNPPNVDALFGTI.
24 ..LNSDDS.TDDE.....S..QPRKP.....IPAWASGNQLSQAVIRQY..YNPPNVDALFGTI.
25 ..------.----.....-..-----.....------------------..-------------.
26 ..LNSDDS.TDDE.....A..HPRKP.....IPTWARGTPLSQAIIHQY..YHPPNLLELFGTI.
27 ..------.----.....-..-----.....------------------..-------------.
28 ..------.----.....-..-----.....------------------..-------------.
29 ..------.----.....-..-----.....------------------..-------------.
30 ..------.----.....-..-----.....------------------..-------------.
31 ..------.----.....-..-----.....------------------..-------------.
32 ..QNSDDS.TDDE.....S..APRKP.....IPSWAEGQIMISSALLDS..CCTTK--------.
33 ..TTED--.----.....-..-----.....------------------..-------------.
34 ..EPDDDD.SDDE.....T..KPKHI.....IPYWAQSQVRKTQLAIQR..YIPEKAVFKFFDTr
35 ..------.----.....-..-----.....------------------..-------------.
36 ..LNSDDE.TDQE.....D..DPRKE.....VPPWADFVIVRQNVRRQVk.NPPFDIAEFFGVI.
37 ..QNSDDS.TDDE.....S..APRKP.....IPSWADSHNLHQIIMKQY..FNPPDLNSFFGVI.
38 ..LNSDDS.TDDE.....N..EPRKP.....VPAWADGSQLNQAILHQY..YHPVNVDQLFGLI.
39 ..LNSDDE.TDQE.....D..DPRKD.....VPAWAEFAVVRENVRRHAi.NPPFDVAQFFGSI.
40 ..------.----.....-..-----.....------------------..-------------.
41 ..------.----.....-..-----.....------------------..-------------.
42 ..LTDDST.DDEStsaskK..SKRPP.....LPAWCSKEERNPTIRTQR..EIKLKVIDQFFSVa
43 ..LTDDST.DDEStsaskK..SKRPP.....LPAWCSKEERNPTIRTQR..EIKLKVIDQFFSVa
44 ..DCHDSD.SEEY.....K..NQKVI.....LKNWEKEVNVMLMQKYES..AIGHAIKNTFFSLq
45 ..HEDDST.DDEG.....KvtHKRPP.....APTWSRSHVRGEAIAMQS..HCPTDIIDSFFSVa
46 ..HEDDST.DDEG.....KvtHKRPP.....APTWSRSHVRGEAIAMQS..HCPTDIIDSFFSVa
47 ..HEDDST.DDEG.....KvtHKRPP.....APTWSRSHVRGEAIAMQS..HCPTDIIDSFFSVa
48 ..LNSDED.TDDE.....N..NPRNE.....IPMWAEFSFVKRSVREHIe.NPPFDLDEFFGKI.
49 tlPDIGSD.SENE.....S..GSHKV.....LAAWAQSPFLEEQLLRQG..--SWDVEQIFGPI.
50 ..LNSDND.TDDE.....N..KPRKE.....IPMWAEFSFVKRSVREHIe.NPPFDLDEFFGKI.
51 ..------.----.....-..-----.....------------------..-------------.
52 ..SESDSD.FERD.....K..SKQKN.....FPKWASDMNI---VNEEYakNLEFNVNTFFGSM.
53 ..------.----.....-..-----.....IPAWASGNLLTQAIRQQY..YKPIDVDRMYGTI.
54 ..--SDDS.DDEG.....N..KKKVN.....LPSWAESPELREQLKRQQ..--KWDPDKIFGMI.
55 ..--SDDS.DDEG.....N..KKKVN.....LPSWAESPELREQLKRQQ..--KWDPDKIFGMI.
56 ..CEDDDEfDDDEem...-..YERNPie7ksIPNWARGEQLEKQLKKQY..L--IDPDEIFFDFp
57 ..------.----.....-..---KT.....IPHWARGEQLEKELKKQY..HINP--DEIFFDFp
880 890 900 910 920
| | | | |
1 .LPLDLEDIFKKSKPRYHK...RTSSAVWNSPPLQGARVPSSLAYSLKKH
2 .LPLDLEDIFKKSKPRYHK...RTSSAVWNSPPLQGARVPSSLAYSLKKH
3 .LPLDLEDIFKKSKPRYHK...RTSSAVWNSPPLQGARVPSSLAYSLKKH
4 .LPLDLEDIFKKSKPRYHK...RTSSAVWNSPPLQGARVPSSLAYSLKKH
5 .LPLDLEDIFKKSKPRYHK...RTSSAVWNSPPLQGARVPSSLAYSLKKH
6 .LPLDLEDIFKKSKPRYHK...RTSSAVWNSPPLQGARVPSSLAYSLKKH
7 .LPLDLEDIFKKSKPRYHK...RTSSAVWNSPPLQGARVPSSLAYSLKKH
8 .LPLDLEDIFKKSKPRYHK...RTSSAVWNSPPLQGARVPSSLAYSLKKH
9 .LPLDLEDIFKKSKPRYHK...RTSSAVWNSPPLQGARVPSSLAYSLKKH
10 .LPLDLEDIFKKSKPRYHK...RTSSAVWNSPPLLGSRLPSSLAYSLKKY
11 .LPLDLEDIFKKSKPRYHK...RTSSAVWNSPPLLGSRLPSSLAYSLKKY
12 .LPLDLEDIFKKRKTRYHK...RTSSAVWNSPPLKATMVP----------
13 .LPLDLEDIFKKRKTRYHK...RTSSAVWNSPPLKATMVP----------
14 .LPLDLEDIFKKRKTRYHK...RTSSAVWNSPPLKATMVP----------
15 .LPLDLEDIFKKRKTRYHK...RTSSAVWNSPPLKATMVP----------
16 .LQLDLEEIFQKSKPRYHK...RTSSAVWNSPPLQGPRVPGSLAYSLKK-
17 .LPLDLEDIFKKRKTRYHK...RTSSAVWNSPPLKATIP-----------
18 .LPLDLEDIFKKRKTRYHK...RTSSAVWNSPPLKATIP-----------
19 .DSPKLEELFYKSKPRYYK...RTSSAVWHSPPLSSNRHHLAVGYGL---
20 .DSPKLEELFNKSKPRYFK...RTSSAVWHSPPLSN-RHHLAVGYGL---
21 .DSPKLEELFNKSKPRYFK...RTSSAVWHSPPLSSNRHHLAVGYGL---
22 .DSPKLEELFNKSKPRYFK...RTSSAVWHSPPLSSNRHHLAVGYGL---
23 .VSPKLEDIFYKSKPRYFK...RTSSAVWNSPPFPGAKSVLGLPYSLKKY
24 .VSPKLEDIFYKSKPRYFK...RTSSAVWNSPPFPGAKSVLGLPYSLKKY
25 .------------------...----------------------------
26 .LPLDLEDIFKKSKPRYHK...RTSSAVWNSPPLQGARVPSSLAYSLKKH
27 .------------------...----------------------------
28 .------------------...----------------------------
29 .------------------...----------------------------
30 .------------------...----------------------------
31 .------------------...----------------------------
32 .------------------...----------------------------
33 .------------------...----------------------------
34 kCTPDLTQLFHGIDRNKLK...RTSSAIWKTPPRYSMM------------
35 .------------------...----------------------------
36 .EKPNLKEIFGDT-VKMKK...RGSSAVWRSPAGPGNVSRT---------
37 .EPPKLEDIFYKSKPRYFK...RTSSAVWHLPP-----------------
38 .ASPKLEDIFGKSKPRYFK...RTSSAVWNSPPGPKSTCGIAC-------
39 .GKPNLKEIFSDA-VKVKK...RGSSAVWKKSPSTLNTSSRTILQD----
40 .------------------...----------------------------
41 .------------------...----------------------------
42 pMTADLREIFPSIDARKLK...RNSSAVWRTPPRYSQMP-----------
43 pMTADLREIFPSIDARKLK...RNSSAVWRTPPRYSQMP-----------
44 aRTPDLQEILEHIEPRKLK...RTSSALWDQPPRFTMIPG----------
45 pTTPDLKQIFPNIDPSQLK...RNSSVLWSTPPRYSEL------------
46 pTTPDLKQIFPNIDPSQLK...RNSSVLWSTPPRYSEL------------
47 pTTPDLKQIFPNIDPSQLK...RNSSVLWSTPPRYSEL------------
48 .EKPNLQEIFGKI------...----------------------------
49 .PPLHIDEIFHSSRLSKLK...SRQS------------------------
50 .EKLN--------------...----------------------------
51 .------------------...----------------------------
52 .EKANLTEIFGEM-VRKKK...RGSSKVW---------------------
53 .DSPKLEELFN--------...----------------------------
54 .KPLQMDEYFRSKDRSKIRfrpRSSSADWS--------------------
55 .KPLQMDEYFRSKDRSKIRfrpRSSSADWS--------------------
56 .MECNLEEIFGTQNQKWAK...RNESGYW---------------------
57 .MECNLEEIFDRTNQKWAK...RNESGYW---------------------