a2m2html output for tmp.a2m

Citations (SAM, SAM-T99, HMMs)

R. Hughey, A. Krogh, Hidden Markov models for sequence analysis: Extension and analysis of the basic method, CABIOS 12:95-107, 1996.
K. Karplus, C. Barrett, R. Hughey, Hidden Markov models for detecting remote protein homologies, Bioinformatics 14(10):846-856, 1998.
A. Krogh et al., Hidden Markov models in computational biology: Applications to protein modeling, JMB 235:1501-1531, Feb 1994.

Sequence numbers correspond to the following labels:

- 2OCY:A|PDBID|CHAIN|SEQUENCE
- gi|119192118|ref|XP_001246665.1|_106:264 hypothetical protein CIMG_00436 [Coccidioides immitis RS]
- gi|90305451|gb|EAS35082.1| hypothetical protein CIMG_00436 [Coccidioides immitis RS]
- gi|145245363|ref|XP_001394949.1|_112:270 hypothetical protein An11g09910 [Aspergillus niger]
- gi|134079649|emb|CAK97075.1| unnamed protein product [Aspergillus niger]
- gi|71000559|ref|XP_754963.1|_130:288 GDP/GTP exchange factor Sec2p, putative [Aspergillus fumigatus Af293]
- gi|66852600|gb|EAL92925.1| GDP/GTP exchange factor Sec2p, putative [Aspergillus fumigatus Af293]
- gi|119493182|ref|XP_001263810.1|_90:248 GDP/GTP exchange factor Sec2p, putative [Neosartorya fischeri NRRL 181]
- gi|119411970|gb|EAW21913.1| GDP/GTP exchange factor Sec2p, putative [Neosartorya fischeri NRRL 181]
- gi|6324057|ref|NP_014127.1|_14:167 Guanyl-nucleotide exchange factor for the small G-protein Sec4p, located on cytoplasmic vesicles; essential for post-Golgi vesicle transport; Sec2p [Saccharomyces cerevisiae]
- gi|134393|sp|P17065|SEC2_YEAST Rab guanine nucleotide exchange factor SEC2 (GDP-GTP exchange factor SEC2) [Taxonomy]
- gi|4439|emb|CAA36395.1| unnamed protein product [Saccharomyces cerevisiae]
- gi|1302336|emb|CAA96180.1| SEC2 [Saccharomyces cerevisiae]
- gi|115402583|ref|XP_001217368.1|_112:270 conserved hypothetical protein [Aspergillus terreus NIH2624]
- gi|114189214|gb|EAU30914.1| conserved hypothetical protein [Aspergillus terreus NIH2624]
- gi|134105121|pdb|2OCY|A_1:154 Chain A, Complex Of The Guanine Exchange Factor Sec2p And The Rab Gtpase Sec4p [Taxonomy]
- gi|134105122|pdb|2OCY|B Chain B, Complex Of The Guanine Exchange Factor Sec2p And The Rab Gtpase Sec4p [Taxonomy]
- gi|83773214|dbj|BAE63341.1|_119:277 unnamed protein product [Aspergillus oryzae]
- gi|121704796|ref|XP_001270661.1|_111:269 GDP/GTP exchange factor Sec2p, putative [Aspergillus clavatus NRRL 1]
- gi|119398807|gb|EAW09235.1| GDP/GTP exchange factor Sec2p, putative [Aspergillus clavatus NRRL 1]
- gi|85118924|ref|XP_965542.1|_126:288 hypothetical protein [Neurospora crassa OR74A]
- gi|28927352|gb|EAA36306.1| hypothetical protein [Neurospora crassa]
- gi|116193833|ref|XP_001222729.1|_122:284 hypothetical protein CHGG_06634 [Chaetomium globosum CBS 148.51]
- gi|88182547|gb|EAQ90015.1| hypothetical protein CHGG_06634 [Chaetomium globosum CBS 148.51]
- gi|46130664|ref|XP_389112.1|_113:275 hypothetical protein FG08936.1 [Gibberella zeae PH-1]
- gi|109097615|ref|XP_001108518.1|_249:411 PREDICTED: similar to RAB3A interacting protein isoform alpha 2 [Macaca mulatta]
- gi|55732642|emb|CAH93020.1|_90:252 hypothetical protein [Pongo pygmaeus]
- gi|10438974|dbj|BAB15391.1|_90:252 unnamed protein product [Homo sapiens]
- gi|41281856|ref|NP_783322.1|_106:268 RAB3A interacting protein isoform alpha 2 [Homo sapiens]
- gi|114645805|ref|XP_001156520.1| PREDICTED: RAB3A interacting protein isoform 5 [Pan troglodytes]
- gi|71152025|sp|Q96QF0|RAB3I_HUMAN RAB3A-interacting protein (Rabin-3) (SSX2-interacting protein) [Taxonomy]
- gi|15387678|emb|CAC59836.1| SSX2 interacting protein RAB3IP, isoform alpha2 [Homo sapiens]
- gi|119617648|gb|EAW97242.1| RAB3A interacting protein (rabin3), isoform CRA_f [Homo sapiens]
- gi|28274699|ref|NP_071901.2|_90:252 RAB3A interacting protein isoform alpha 1 [Homo sapiens]
- gi|15387676|emb|CAC59835.1| SSX2 interacting protein RAB3IP, isoform alpha1 [Homo sapiens]
- gi|119617643|gb|EAW97237.1| RAB3A interacting protein (rabin3), isoform CRA_a [Homo sapiens]
- gi|114645809|ref|XP_001156402.1|_90:252 PREDICTED: RAB3A interacting protein isoform 4 [Pan troglodytes]
- gi|41281871|ref|NP_783323.1|_90:252 RAB3A interacting protein isoform beta 1 [Homo sapiens]
- gi|15387680|emb|CAC59837.1| SSX2 interacting protein RAB3IP, isoform beta1 [Homo sapiens]
- gi|119617645|gb|EAW97239.1| RAB3A interacting protein (rabin3), isoform CRA_c [Homo sapiens]
- gi|41281862|ref|NP_783324.1|_106:268 RAB3A interacting protein isoform beta 2 [Homo sapiens]
- gi|15387682|emb|CAC59838.1| SSX2 interacting protein RAB3IP, isoform beta2 [Homo sapiens]
- gi|119617647|gb|EAW97241.1| RAB3A interacting protein (rabin3), isoform CRA_e [Homo sapiens]
- gi|114645811|ref|XP_001156177.1|_90:252 PREDICTED: RAB3A interacting protein isoform 1 [Pan troglodytes]
- gi|15387686|emb|CAC59840.1|_106:268 SSX2 interacting protein RAB3IP, isoform gamma2 [Homo sapiens]
- gi|119617644|gb|EAW97238.1| RAB3A interacting protein (rabin3), isoform CRA_b [Homo sapiens]
- gi|114645813|ref|XP_001156228.1|_90:252 PREDICTED: RAB3A interacting protein isoform 2 [Pan troglodytes]
- gi|15387684|emb|CAC59839.1|_90:252 SSX2 interacting protein RAB3IP, isoform gamma1 [Homo sapiens]
- gi|119617646|gb|EAW97240.1| RAB3A interacting protein (rabin3), isoform CRA_d [Homo sapiens]
- gi|55725098|emb|CAH89416.1|_106:268 hypothetical protein [Pongo pygmaeus]
- gi|114052362|ref|NP_001039812.1|_90:252 hypothetical protein LOC533284 [Bos taurus]
- gi|86438038|gb|AAI12788.1| Similar to RAB3A interacting protein isoform alpha 1 [Bos taurus]
- gi|67537178|ref|XP_662363.1|_107:261 hypothetical protein AN4759.2 [Aspergillus nidulans FGSC A4]
- gi|40741611|gb|EAA60801.1| hypothetical protein AN4759.2 [Aspergillus nidulans FGSC A4]
- gi|37589535|gb|AAH59358.1|_90:252 RAB3IP protein [Homo sapiens]
- gi|73968740|ref|XP_538280.2|_137:299 PREDICTED: similar to RAB3A interacting protein isoform alpha 2 [Canis familiaris]
- gi|39970913|ref|XP_366847.1|_70:232 hypothetical protein MGG_02923 [Magnaporthe grisea 70-15]
- gi|86196641|gb|EAQ71279.1| hypothetical protein MGCH7_ch7g686 [Magnaporthe grisea 70-15]
- gi|145017252|gb|EDK01615.1| hypothetical protein MGG_02923 [Magnaporthe grisea 70-15]
- gi|71004068|ref|XP_756700.1|_142:300 hypothetical protein UM00553.1 [Ustilago maydis 521]
- gi|46095969|gb|EAK81202.1| hypothetical protein UM00553.1 [Ustilago maydis 521]
- gi|68467412|ref|XP_722139.1|_15:161 hypothetical protein CaO19_4928 [Candida albicans SC5314]
- gi|46444088|gb|EAL03365.1| hypothetical protein CaO19.4928 [Candida albicans SC5314]
- gi|68467183|ref|XP_722253.1|_15:161 hypothetical protein CaO19_12394 [Candida albicans SC5314]
- gi|46444212|gb|EAL03488.1| hypothetical protein CaO19.12394 [Candida albicans SC5314]
- gi|89267086|emb|CAJ41931.1|_133:291 ATPase [Ustilago hordei]
- gi|111070547|gb|EAT91667.1|_86:244 hypothetical protein SNOG_00172 [Phaeosphaeria nodorum SN15]
- gi|50304687|ref|XP_452299.1|_14:160 unnamed protein product [Kluyveromyces lactis]
- gi|49641432|emb|CAH01150.1| unnamed protein product [Kluyveromyces lactis NRRL Y-1140]
- gi|50291267|ref|XP_448066.1|_15:168 unnamed protein product [Candida glabrata]
- gi|49527377|emb|CAG61017.1| unnamed protein product [Candida glabrata CBS 138]
- gi|19114094|ref|NP_593182.1|_28:177 hypothetical protein SPAC23C4.10 [Schizosaccharomyces pombe 972h-]
- gi|52783341|sp|O13930|SEC2_SCHPO Rab guanine nucleotide exchange factor sec2 (GDP-GTP exchange factor sec2) [Taxonomy]
- gi|2465152|emb|CAB16881.1| SPAC23C4.10 [Schizosaccharomyces pombe]
- gi|50422705|ref|XP_459929.1|_18:164 hypothetical protein DEHA0E14916g [Debaryomyces hansenii CBS767]
- gi|49655597|emb|CAG88173.1| unnamed protein product [Debaryomyces hansenii CBS767]
- gi|45199189|ref|NP_986218.1|_23:176 AFR670Wp [Ashbya gossypii ATCC 10895]
- gi|44985329|gb|AAS54042.1| AFR670Wp [Ashbya gossypii ATCC 10895]
- gi|134104227|pdb|2E7S|A_6:135 Chain A, Crystal Structure Of The Yeast Sec2p Gef Domain
- gi|134104228|pdb|2E7S|B Chain B, Crystal Structure Of The Yeast Sec2p Gef Domain
- gi|134104229|pdb|2E7S|C Chain C, Crystal Structure Of The Yeast Sec2p Gef Domain
- gi|134104230|pdb|2E7S|D Chain D, Crystal Structure Of The Yeast Sec2p Gef Domain
- gi|134104231|pdb|2E7S|E Chain E, Crystal Structure Of The Yeast Sec2p Gef Domain
- gi|134104232|pdb|2E7S|F Chain F, Crystal Structure Of The Yeast Sec2p Gef Domain
- gi|134104233|pdb|2E7S|G Chain G, Crystal Structure Of The Yeast Sec2p Gef Domain
- gi|134104234|pdb|2E7S|H Chain H, Crystal Structure Of The Yeast Sec2p Gef Domain
- gi|134104235|pdb|2E7S|I Chain I, Crystal Structure Of The Yeast Sec2p Gef Domain
- gi|134104236|pdb|2E7S|J Chain J, Crystal Structure Of The Yeast Sec2p Gef Domain
- gi|134104237|pdb|2E7S|K Chain K, Crystal Structure Of The Yeast Sec2p Gef Domain
- gi|134104238|pdb|2E7S|L Chain L, Crystal Structure Of The Yeast Sec2p Gef Domain
- gi|134104239|pdb|2E7S|M Chain M, Crystal Structure Of The Yeast Sec2p Gef Domain
- gi|134104240|pdb|2E7S|N Chain N, Crystal Structure Of The Yeast Sec2p Gef Domain
- gi|134104241|pdb|2E7S|O Chain O, Crystal Structure Of The Yeast Sec2p Gef Domain
- gi|134104242|pdb|2E7S|P Chain P, Crystal Structure Of The Yeast Sec2p Gef Domain
- gi|134104243|pdb|2E7S|Q Chain Q, Crystal Structure Of The Yeast Sec2p Gef Domain
- gi|134104244|pdb|2E7S|R Chain R, Crystal Structure Of The Yeast Sec2p Gef Domain
- gi|134104245|pdb|2E7S|S Chain S, Crystal Structure Of The Yeast Sec2p Gef Domain
- gi|134104246|pdb|2E7S|T Chain T, Crystal Structure Of The Yeast Sec2p Gef Domain
- gi|66472590|ref|NP_001018417.1|_58:217 hypothetical protein LOC553605 [Danio rerio]
- gi|63100634|gb|AAH95215.1| Zgc:110270 [Danio rerio]
- gi|114645807|ref|XP_001156344.1|_90:224 PREDICTED: hypothetical protein isoform 3 [Pan troglodytes]
- gi|126275726|ref|XP_001386895.1|_14:160 predicted protein [Pichia stipitis CBS 6054]
- gi|126212764|gb|EAZ62872.1| predicted protein [Pichia stipitis CBS 6054]
- gi|116506542|gb|EAU89437.1|_73:219 hypothetical protein CC1G_07663 [Coprinopsis cinerea okayama7#130]
- gi|58260096|ref|XP_567458.1|_127:284 hypothetical protein CNJ00770 [Cryptococcus neoformans var. neoformans JEC21]
- gi|134116648|ref|XP_772996.1| hypothetical protein CNBJ2720 [Cryptococcus neoformans var. neoformans B-3501A]
- gi|50255616|gb|EAL18349.1| hypothetical protein CNBJ2720 [Cryptococcus neoformans var. neoformans B-3501A]
- gi|57229508|gb|AAW45941.1| hypothetical protein CNJ00770 [Cryptococcus neoformans var. neoformans JEC21]
- gi|50557072|ref|XP_505944.1|_14:169 hypothetical protein [Yarrowia lipolytica]
- gi|49651814|emb|CAG78756.1| unnamed protein product [Yarrowia lipolytica CLIB122]
- gi|121716820|ref|XP_001275919.1|_156:253 conserved hypothetical protein [Aspergillus clavatus NRRL 1]
- gi|119404076|gb|EAW14493.1| conserved hypothetical protein [Aspergillus clavatus NRRL 1]
- gi|71002588|ref|XP_755975.1|_164:250 Sec2p domain protein, putative [Aspergillus fumigatus Af293]
- gi|66853613|gb|EAL93937.1| conserved hypothetical protein [Aspergillus fumigatus Af293]
- gi|145251383|ref|XP_001397205.1|_170:252 hypothetical protein An15g06770 [Aspergillus niger]
- gi|134082737|emb|CAK42629.1| unnamed protein product [Aspergillus niger]
- gi|83771183|dbj|BAE61315.1|_160:242 unnamed protein product [Aspergillus oryzae]
- gi|46125893|ref|XP_387500.1|_440:536 hypothetical protein FG07324.1 [Gibberella zeae PH-1]
- gi|119482151|ref|XP_001261104.1|_164:246 conserved hypothetical protein [Neosartorya fischeri NRRL 181]
- gi|119409258|gb|EAW19207.1| conserved hypothetical protein [Neosartorya fischeri NRRL 181]
- gi|67900730|ref|XP_680621.1|_193:275 hypothetical protein AN7352.2 [Aspergillus nidulans FGSC A4]
- gi|40742533|gb|EAA61723.1| hypothetical protein AN7352.2 [Aspergillus nidulans FGSC A4]
- gi|111061328|gb|EAT82448.1|_147:242 hypothetical protein SNOG_10113 [Phaeosphaeria nodorum SN15]
- gi|115387951|ref|XP_001211481.1|_165:242 predicted protein [Aspergillus terreus NIH2624]
- gi|114195565|gb|EAU37265.1| predicted protein [Aspergillus terreus NIH2624]
- gi|39947770|ref|XP_363043.1|_221:317 hypothetical protein MGG_08627 [Magnaporthe grisea 70-15]
- gi|145010250|gb|EDJ94906.1| hypothetical protein MGG_08627 [Magnaporthe grisea 70-15]
- gi|116508099|gb|EAU90994.1|_77:227 predicted protein [Coprinopsis cinerea okayama7#130]
- gi|116197967|ref|XP_001224795.1|_214:312 hypothetical protein CHGG_07139 [Chaetomium globosum CBS 148.51]
- gi|88178418|gb|EAQ85886.1| hypothetical protein CHGG_07139 [Chaetomium globosum CBS 148.51]
- gi|85102292|ref|XP_961310.1|_252:346 hypothetical protein [Neurospora crassa OR74A]
- gi|28922853|gb|EAA32074.1| hypothetical protein [Neurospora crassa]
- gi|12718207|emb|CAC28751.1|_217:311 related to TFIID and SAGA subunit TAF61 [Neurospora crassa]

                         10         20           30                  40
                         |          |            |                   |
   1 ...SM...A....LSTQLI.ES.VDKQSHLEEQLNKS...LKTIASQ...KAAI.E.N....Y.N
   2 sneVA...A....LSDKLI.QA.INNQTVLDDTLAAT...RQELELS...RERV.L.Q....L.E
   3 sneVA...A....LSVKLV.QA.INNQTTLDDNLVAT...RQELEQA...QAKI.R.V....L.E
   4 sseVA...A....LSVKLI.QA.INNQTTLDDNLVAT...RQELEQA...QNRI.K.S....L.E
   5 sseVA...A....LSVKLI.QA.INNQTTLDDNLVAT...RQELEQA...QNRI.K.S....L.E
   6 siqVT...S....LSTQLI.ES.VDKQSHLEEQLNKS...LKTIASQ...KAAI.E.N....Y.N
   7 sseVA...A....LSVKLV.EA.INTQTTLDDNLVAA...RQELEQA...RNRI.Q.T....L.E
   8 ...SX...A....LSTQLI.ES.VDKQSHLEEQLNKS...LKTIASQ...KAAI.E.N....Y.N
   9 sneVA...A....LSVKLV.QA.INNQTTLDDTLVAT...RQELEQA...QTKI.R.T....L.E
  10 sseVA...A....LSVKLI.QA.INNQTTLDDSLVAT...RQELEQA...QNRL.K.S....L.E
  11 dqeVA...T....LSTKLI.NA.INHQTTLDDNLSQT...KMELEQA...RDKI.R.Q....L.E
  12 ndeVA...T....LSTKLI.NA.INHQTTLDDNLSAT...RVELERS...RERI.H.Q....L.E
  13 ndeVA...T....LSNKLI.NA.INHQTILDDSLSAA...RHELDAA...RDRI.R.D....L.E
  14 vtdPA...P....CSTSGV.TAgLTKLTTRKDNYNAE...REFLQGAti.TEAC.D.GsddiF.G
  15 vtdPA...P....CSTSGV.TAgLTKLTTRKDNYNAE...REFLQGAti.TEAC.D.GsddiF.G
  16 vtdPA...P....CSTSGV.TAgLTKLTTRKDNYNAE...REFLQGAti.TEAC.D.GsddiF.G
  17 vtdPA...P....CSTSGV.TAgLTKLTTRKDNYNAE...REFLQGAti.TEAC.D.GsddiF.G
  18 vtdPA...P....CSTSGV.TAgLTKLTTRKDNYNAE...REFLQGAti.TEAC.D.GsddiF.G
  19 vtdPA...P....CSTSGV.TAgLTKLTTRKDNYNAE...REFLQGAti.TEAC.D.GsddiF.G
  20 vtdPA...P....CSTSGV.TAgLTKLTTRKDNYNAE...REFLQGAti.TEAC.D.GsddiF.G
  21 vtdPA...P....CSTSGV.TAgLTKLTTRKDNYNAE...REFLQGAti.TEAC.D.GsddiF.G
  22 vtdPA...P....CSTSGV.TAgLTKLTTRKDNYNAE...REFLQGAti.TEAC.D.GsddiF.G
  23 vtdPA...P....CSTSGV.TAgLTKLTTRKDNYNAE...REFLQGAti.TEAC.D.GsddiF.G
  24 vtdPA...P....CSTSGV.TAgLTKLTTRKDNYNAE...REFLQGAti.TEAC.D.GsddiF.G
  25 vtdPA...P....CSTSGV.TAgLTKLTTRKDNYNAE...REFLQGAti.TEAC.D.GsddiF.G
  26 vtdPA...P....CSTSGV.TAgLTKLTTRKDNYNAE...REFLLGAti.TEAC.D.GsddiF.G
  27 gtdPA...P....CSTSGV.TAgILKLTTRKDNCSAE...REFLQGAti.TEAC.D.GsddiF.G
  28 ndeVA...T....LSLKLV.QA.INNQTKLDDTLAVT...RQELEQV...QEKA.R.A....L.E
  29 vtdPA...P....CSTSGV.TAgLTKLTTRKDNYNAE...REFLQGAti.TEAC.D.GsddiF.G
  30 vtdPT...P....CSTSGVtTG.LTKLTTRKDNCNAE...REFLQGAti.TEAC.D.GsddiF.G
  31 dleVA...T....LSTKLI.NA.INHQTTLDDTLSRA...RAELEDA...RETI.R.Q....LeG
  32 tnqVT...S....LNEKLV.RS.FNRIADLEDDYSDA...QERVQGM...SAKI.K.E....L.E
  33 aeeVG...S....LSTRLV.TA.VNKQVELEETILEL...RKQVSAL...KLKN.E.Q....L.N
  34 aeeVG...S....LSTRLV.TA.VNKQVELEETILEL...RKQVSAL...KLKN.E.Q....L.N
  35 inqVT...G....LNEKLV.KS.FNRIADLEDDYSDA...QERVRIM...SAKI.K.E....L.E
  36 sqeVS...M....LSTKLI.NA.INHSTMLDDSLQQT...RHELETA...REQL.A.G....L.E
  37 slqVT...S....LSTQLI.ES.IDKQSQLEEQLLVA...KKTISTQ...QNIA.N.S....Y.N
  38 svqVS...T....LSTQLI.ES.IDRQSELEKRLRDA...QIIINKQ...KHVM.H.E....F.E
  39 ...MSqeeI....LSQKLV.AA.IERQAALDDKYATE...VHRNEAL...SERI.R.E....L.E
  40 teeVT...L....LSTKLV.TA.VAKQLELEEKLLHM...HRDNGQL...KQKL.S.K....L.G
  41 svqVS...S....LSTQLI.ES.IDKQSRLEEQLQHA...KKALAAQ...KDVV.K.Q....C.E
  42 ...--...-....------.--.---LGSLEEQLNKS...LKTIASQ...KAAI.E.N....Y.N
  43 ...-A...LradqLPTQPV.YS.APRHLGGDDTLNGSgndPAAVDAV...DADGeD.G....L.G
  44 vtdPA...P....CSTSGV.TAgLTKLTTRKDNYNAE...REFLQGAti.TEAC.D.GsddiF.G
  45 taeIT...L....LSTKLV.TA.VAKQLDLEEAVLHL...RKELQLA...KLEQ.R.R....Y.E
  46 fsqVT...E....LNNKLV.KS.YDRVSDLEDDLHVA...SANLRTS...SVRI.S.Q....L.E
  47 sdqTH...A....LNSKLI.AS.ISHSADLEDELQLV...RDRHVAL...GERA.K.S....L.E
  48 ...--...-....----AP.MS.VETQTQTQQHAHVG...PAQMASA...SAAS.SvH....I.K
  49 ...--...-....------.--.--------------...-------...----.-.-....-.-
  50 ...--...-....------.--.--------------...-------...----.-.-....-.-
  51 ...--...-....------.--.--------------...-------...----.-.-....-.-
  52 ...--...-....------.--.--------------...-------...----.-.-....-.-
  53 ...--...-....------.--.--------------...-------...----.-.-....-.-
  54 ...--...-....------.--.--------------...-------...----.-.-....-.-
  55 ...--...-....------.--.--------------...-------...----.-.-....-.-
  56 ...--...-....------.--.--------------...-------...----.-.-....-.-
  57 ...--...-....------.--.--------------...-------...----.-.-....-.-
  58 ...--...-....------.--.--------------...-------...----.-.-....-.-
  59 isrVC...E....LSNSLS.EA.YKAQAELEVQLNVA...KSNLQLVimnNEML.E.Ea...L.K
  60 ...--...-....------.--.--------------...-------...----.-.-....-.-
  61 ...--...-....------.--.--------------...-------...----.-.-....-.-
  62 ...--...-....------.--.--------------...-------...----.-.-....-.-


                    50               60                     70         
                    |                |                      |         
   1 .QLK.EDY.N.T.L.KRELSD.....RDD.E.VK....R....LREDI....AK.ENELRTKAEE
   2 .EEN.KKHqE.D.I.SNGILI.....RHD.K.VEsekmQ....LKKEL....EE.ERGRRMIVER
   3 .LEN.EKY.KrD.I.DQEVLIkksd.VDY.E.ML....R....LQAAL....AE.EKAQRALVEK
   4 .SEN.EKY.RhD.I.EQAVLIkkad.ADR.E.IS....Q....LKAAL....AE.EKAQRAIVEK
   5 .SEN.EKY.RhD.I.EQAVLIkkad.ADR.E.IS....Q....LKAAL....AE.EKAQRAIVEK
   6 .QLK.EDY.N.T.L.KRELSD.....RDD.E.VK....R....LREDI....AK.ENELRTKAEE
   7 .TEN.EKYrR.D.I.EQEVLV.....KKS.D.YEyeimR....LKAAL....AD.EKAQRALVEK
   8 .QLK.EDY.N.T.L.KRELSD.....RDD.E.VK....R....LREDI....AK.ENELRTKAEE
   9 .SEN.EKYrR.D.I.DQEVFIkkad.VDY.E.IL....R....LKAAL....AD.EKAQRALVEK
  10 .SEN.ERY.RqD.I.EQQILIkkvd.ADL.E.IS....G....LQAAL....AE.EKTQRAVVEK
  11 rTVE.EQR.E.M.L.AGDVWV.....RRK.T.VE....A....EKTTLlgviAE.EKQARLDVEQ
  12 aKVE.EQR.E.M.L.AGDVWV.....RRK.T.VE....A....EKAKLvaraAE.EKRARLDMEQ
  13 .TQNaSQR.E.M.L.AGDVWV.....RKH.T.VE....AekkvWQAKI....AV.ERQKRLDTEM
  14 .LST.DSL.S.R.LrSPSVLE.....VRE.KgYE....R....LKEEL....AKaQRELKLKDEE
  15 .LST.DSL.S.R.LrSPSVLE.....VRE.KgYE....R....LKEEL....AKaQRELKLKDEE
  16 .LST.DSL.S.R.LrSPSVLE.....VRE.KgYE....R....LKEEL....AKaQRELKLKDEE
  17 .LST.DSL.S.R.LrSPSVLE.....VRE.KgYE....R....LKEEL....AKaQRELKLKDEE
  18 .LST.DSL.S.R.LrSPSVLE.....VRE.KgYE....R....LKEEL....AKaQRELKLKDEE
  19 .LST.DSL.S.R.LrSPSVLE.....VRE.KgYE....R....LKEEL....AKaQRELKLKDEE
  20 .LST.DSL.S.R.LrSPSVLE.....VRE.KgYE....R....LKEEL....AKaQRELKLKDEE
  21 .LST.DSL.S.R.LrSPSVLE.....VRE.KgYE....R....LKEEL....AKaQRELKLKDEE
  22 .LST.DSL.S.R.LrSPSVLE.....VRE.KgYE....R....LKEEL....AKaQRELKLKDEE
  23 .LST.DSL.S.R.LrSPSVLE.....VRE.KgYE....R....LKEEL....AKaQRELKLKDEE
  24 .LST.DSL.S.R.LrSPSVLE.....VRE.KgYE....R....LKEEL....AKaQRELKLKDEE
  25 .LST.DSL.S.R.LrSPSVLE.....VRE.KgYE....R....LKEEL....AKaQRELKLKDEE
  26 .LST.DSL.S.R.LrSPSVLE.....VRE.KgYE....R....LKEEL....AKaQRELKLKDEE
  27 .LST.DSL.S.R.LrSPSVLE.....VRE.KgYE....R....LKEEL....AKaQRELKLKDEE
  28 .SEN.EQYwR.D.I.EDGALV.....KKA.E.VD....Q....LKASL....AE.EKAQRLLAEK
  29 .LST.DSL.S.R.LrSQSVLE.....VRE.KgYE....R....LKEEL....AKaQRELKLKDEE
  30 .LST.DSL.S.R.LrSPSVLE.....VRE.KgYE....R....LKEEL....AKaQRELKLKDEE
  31 .RLA.EQR.E.M.L.SGDVWV.....RRK.T.VE....S....EKKDLlrrvAD.EKKARYEMEH
  32 .KERaEHL.D.A.L.NTGLLVekah.VSS.E.MQ....R....MMDRV....IE.ETAQRGKAES
  33 .QSD.IKL.K.T.I.LPKYIK.....LQD.D.YR....-....--ETL....TK.KKE----AES
  34 .QSD.IKL.K.T.I.LPKYIK.....LQD.D.YR....-....--ETL....TK.KKE----AES
  35 .KERaEHL.D.A.L.NTGLLVekah.VSN.E.MQ....R....MMDRV....IE.ETAQRGKAES
  36 aKVQ.EHE.K.Q.V.SRGLLVekv..VYD.K.ME....Kq...LGIEL....QE.ERNRRIAAEA
  37 .ELK.QEL.Q.S.L.K-----.....--L.Q.YE....T....DKTKF....KK.QEEICADAEK
  38 .TLK.QKN.K.E.L.SDGQQS.....FEE.K.IR....A....LSAQL....EE.EKSKRLAAEK
  39 .AKL.SAK.K.S.F.DEELVK.....FHN.-.--....-....LEEKL....QL.TETKCRNAES
  40 .DIE.TKY.N.E.-.------.....VVP.K.YE....E....IKKDH....EK.MKELKLTAEA
  41 .SAR.GEA.Q.Q.L.RSQLAD.....RDT.E.LE....R....QGEEL....EE.ARKARLAAEL
  42 .QLK.EDY.N.T.L.KRELSD.....RDD.E.VK....R....LREDI....AK.ENELRTKAEE
  43 .LST.DSL.S.R.LrSPSVME.....VRE.KgYE....K....LKEEL....AKaQRELKLKDEE
  44 .LST.DSL.S.R.LrSPSVLE.....VRE.KgYE....R....LKEEL....AKaQRELKLKDEE
  45 .LDS.AKY.K.E.L.------.....-VP.R.YT....K....LREDF....QT.TEDKMRLAET
  46 mERT.QHL.A.A.L.NTGLLVeksh.VTT.E.LN....R....LMEKA....TE.EAAQRGQAES
  47 .EER.NRW.E.EsM.KTGLLVerdq.IRD.E.MQ....R....LAAGL....VE.EERRRGSAEE
  48 .ELT.QEV.S.S.L.STRLLQ.....AME.T.QS....E....LEEELgr..EK.RDKDRANVEN
  49 .---.TAA.Q.P.V.PSNPTI.....PDE.T.TT....E....LQNAL....QR.EQNLRRAAES
  50 .---.---.-.-.-.------.....---.V.TT....E....LQTAL....ER.EQSLRKAAES
  51 .---.---.-.-.-.------.....---.E.TV....E....LQNAL....NR.EQSLRKAAES
  52 .---.---.-.-.-.------.....---.H.TA....E....LQSAL....DR.EQSLRRAAES
  53 .---.---.-.-.-.------.....--P.S.AE....D....LLAAL....NR.EQSLRKEAEG
  54 .---.---.-.-.-.------.....---.V.TT....E....LQTAL....ER.EQSLRKAAES
  55 .---.---.-.-.-.------.....---.E.TL....E....LQNAL....NR.EQSLRKAAET
  56 .---.---.-.-.-.------.....---.A.DT....E....LLNEL....ER.ERALRAKAEE
  57 .---.---.A.R.P.SPPPQP.....AHE.D.TV....E....LQNAL....SR.EQNLRRAAES
  58 .---.---.-.-.-.--QLRV.....TGDqT.MD....D....LLVAL....TR.EQQLRAAAEA
  59 .KNN.AAA.R.D.L.GPSNLTs11vnHAK.E.IE....E....LTAEL....EK.ERAAKKKIVQ
  60 .---.---.-.-.-.------.....AQL.T.PS....D....LLSAL....SR.EQALRAEAEG
  61 .---.---.-.-.-.------.....---.-.--....-....-KSLH....TE.TRAKLAKAEA
  62 .---.---.-.-.-.------.....---.-.--....-....-KSLH....TE.TRAKLAKAEA


      80             90       100               110           120      
      |              |         |                 |             |      
   1 .E.....ADKLNKEVEDLTASLFDEANNMV....ADARK....EK....YAIEILNKRLTEQLRE
   2 .E.....KKGIEQELADLTAALFEEANKMV....AAAKK....ER....EAVEKRNEQLQAQIKD
   3 .E.....KKGIEQELETLTAALFEEANKMV....AAAKL....ER....EAVEKKNEQLRSQVKD
   4 .S.....KKTIEQELETLTAALFEEANKMV....AAAKL....ER....EAVEKKNEQLRAQVKD
   5 .G.....KKTIEQELETLTAALFEEANKMV....AAAKL....ER....EAVEKKNEQLRAQVKD
   6 .E.....ADKLNKEVEDLTASLFDEANNMV....ADARK....EK....YAIEILNKRLTEQLRE
   7 .E.....KKGIEQELETLTAALFEEANKMV....AAAKH....ER....EAVEKKNEQLRSQVKD
   8 .E.....ADKLNKEVEDLTASLFDEANNXV....ADARK....EK....YAIEILNKRLTEQLRE
   9 .E.....KKGIEQELETLTAALFEEANKMV....AAAKL....ER....EAVEKKNEQLRAQVKD
  10 .G.....KKTIEQELETLTAALFEEANKMV....AAAKL....ER....EAVEKKNEQLRAQVKD
  11 .Q.....KKKIEQELENLTAALFEEANKMVisakEEARI....EQ....EILQRKNDQLRAQLVD
  12 .Q.....KKKIEQELENLTTALFEEANNMVisakEDARA....EQ....EALHRKNEQLRAQLAD
  13 .E.....KKKIEQELENLTAALFEEANKMV....IAAKE....EAkadhEVLQRKNDQLKSQLAD
  14 cErlskvRDQLGQELEELTASLFEEAHKMV....REANI....KQ....ATAEK-------QLKE
  15 cErlskvRDQLGQELEELTASLFEEAHKMV....REANI....KQ....ATAEK-------QLKE
  16 cErlskvRDQLGQELEELTASLFEEAHKMV....REANI....KQ....ATAEK-------QLKE
  17 cErlskvRDQLGQELEELTASLFEEAHKMV....REANI....KQ....ATAEK-------QLKE
  18 cErlskvRDQLGQELEELTASLFEEAHKMV....REANI....KQ....ATAEK-------QLKE
  19 cErlskvRDQLGQELEELTASLFEEAHKMV....REANI....KQ....ATAEK-------QLKE
  20 cErlskvRDQLGQELEELTASLFEEAHKMV....REANI....KQ....ATAEK-------QLKE
  21 cErlskvRDQLGQELEELTASLFEEAHKMV....REANI....KQ....ATAEK-------QLKE
  22 cErlskvRDQLGQELEELTASLFEEAHKMV....REANI....KQ....ATAEK-------QLKE
  23 cErlskvRDQLGQELEELTASLFEEAHKMV....REANI....KQ....ATAEK-------QLKE
  24 cErlskvRDQLGQELEELTASLFEEAHKMV....REANI....KQ....ATAEK-------QLKE
  25 cErlskvRDQLGQELEELTASLFEEAHKMV....REANI....KQ....ATAEK-------QLKE
  26 cErlskvRDQLGQELEELTASLFEEAHKMV....REANI....KQ....ATAEK-------QLKE
  27 cErlskvRDQLGQELEELTASLFEEAHKMV....REANV....KQ....ATAEK-------QLKE
  28 .E.....KKGIEQELETLTAALFEEANKMV....AAAKL....ER....EAVEKKNEQLRSQIKD
  29 cErlskvRDQLGQELEELTASLFEEAHKMV....REANI....KQ....ATAEK-------QLKE
  30 cErlskvRDQLGQELEELTASLFEEAHKMV....REANV....KQ....ATAEK-------QLKE
  31 .Q.....KKKIEQELEELSTQLFEEAQKMViaakEDAQK....EQ....EILHNKNEKLRDQLSN
  32 .D.....KSKIEAELDELSSSLFSEANKMV....AVERL....SR....ARAEEKSRNMEERLKD
  33 .Q.....NTKLQGEVEDLTASLFDEANTMV....SNASR....ET....HNFKIKNRKLYEELDE
  34 .Q.....NTKLQGEVEDLTASLFDEANTMV....SNASR....ET....HNFKIKNRKLYEELDE
  35 .D.....KSKIEAELDELSSSLFSEANKMV....AVERL....SR....ARAEEKSRNMEERLKD
  36 .A.....KRKTDSEVEALTAALFEEANVMV....AAARK....ET....EASEKRGEHFKQQIAD
  37 .K.....VATLNQEIEDLTASLFDEANNMV....ADARK....EQ....NAVEILNSKLKEQLKE
  38 .E.....VDKLGQEVEDLTASLFDEANNMV....SDARR....EK....HDIEIQNSRLQETLKE
  39 .E.....KSRVENELEDLTSSLFEEANRMV....ANARK....ET....VASEKRVNQLKKQLVD
  40 .Q.....NTKLLAEVEDLTASLFNEANEMV....SNASR....EA....YNFKVKNRKLNEEIEE
  41 .A.....VERLNKEIEDLTTSLFDEANRMV....SKARK....EK....HVVEQHNARLQEQLRE
  42 .E.....ADKLNKEVEDLTASLFDEANNLV....ADARX....EK....YAIEILNKRLTEQLRE
  43 cErlskvRDQLGQELEELTASLFEEAHKMV....HEANL....KQ....ATAEK-------QLKE
  44 cErlskvRDQLGQELEELTASLFEEAHKMV....REANI....KQ....ATAEK-------QLKE
  45 .E.....RTRLEHEVEDLTASLFDEANTRV....SNAAR....ET....HNYKVKNKKLQEELEE
  46 .A.....RAAIEKDLDDLSASLFDQANTMV....AEARF....AQ....HLSEQKVVEAERALKG
  47 .K.....RAQVENEVDDLTAKLFDQANTMV....ATERM....SR....AQAEARLRSTEENLAN
  48 .KelkteVQNLREEMQELSAELFDEANNMV....SDARRdaakEV....AETKKRNDQLKVQLEE
  49 .Q.....LSQASTELEELTAQLFSQANEMV....AQERK....AR....AKLEERVAVLEHRDVE
  50 .Q.....LTQASSELEKLTAQLFSQANEMV....AQERK....AR....ARLEERVAVLERRDVE
  51 .Q.....LSQASTELEELTAQLFSQANEMV....AQERK....AR....ARLEERVAVLERRDVE
  52 .Q.....LSQASSELEELTAQLFSQANEMV....AQERK....AR....ARLEERVAVLERRDVE
  53 .K.....VAATSQEVEELSAALFEEANKMV....AEERR....AR....AKLEQRVDELERRDME
  54 .Q.....LSQASSELEELTAQLFSQANEMV....AQERK....AR....AKLEERVAVLERRDVE
  55 .Q.....LTQASTELEELTAQLFSQANEMV....AQERK....AR....ARLEERVAVLERRDIE
  56 .R.....AEKVDSEIEELSVQLFSQANEMV....ATERK....AR....AKLEERIEILERKDKD
  57 .Q.....LSQTTTELEELTAQLFSQANEMV....AQERK....AR....ARLEERVALLERCDVE
  58 .R.....ELDASREVEELSASLFEEANEMV....ATERR....AR....AKLEERVDILEKRDVE
  59 .E.....KAALEDELESLSQALFEEANKMV....AQERM....KL....AETEE---ELKETRKE
  60 .R.....LSETSREVEELSASLFEQANEMV....AAERR....AR....ARLEQRVGELERREGD
  61 .K.....LTATSREIEELSVTLFSEANEMV....ASERR....AR....AKLEERVKTLEKRDEQ
  62 .K.....LTATSREIEELSVTLFSEANEMV....ASERR....AR....AKLEERVKTLEKRDEQ


        130          140             150                 
         |            |               |                 
   1 K.DTL...LDTLTLQLKNL...KKVMHSLD...N...E.S.T...V.....
   2 T.ETL...LASHQEQLAEL...KLVMQHMHsdrD...D.S.D...M.....
   3 T.EAL...LASHQEQLAEL...KSVLQGPN...IakeD.S.E...T.....
   4 T.ELL...LASHQEQLAEL...KSVMQGMN...I...A.K.DdveV.....
   5 T.ELL...LASHQEQLAEL...KSVMQGMN...I...A.K.DdveV.....
   6 K.DTL...LDTLTLQLKNL...KKVMHSLD...N...E.S.T...Vtnn..
   7 T.ESL...LASQQEQLSEL...KAVLQGMN...V...P.ReD...Iet...
   8 K.DTL...LDTLTLQLKNL...KKVXHSLD...N...E.S.T...V.....
   9 T.ESL...VASHQEQLAEL...KSVLQEMN...I...TkD.D...Iea...
  10 T.ELL...LASHQEQLAEL...KSVMQGMN...La..K.D.D...Vdt...
  11 T.EGL...LKSQQEQLAEL...KHLMEDMS...A...E.K.Heq.Ip....
  12 T.EGL...LRSQQEQLVEL...KHVMEQMTverE...E.Q.P...P.....
  13 T.ESI...LKSQQEQLVEL...KHVMEHMA...A...G.R.E...Ehtn..
  14 A.QGK...IDVLQAEVAAL...KTLVLSSS...P...T.S.P...Tqep..
  15 A.QGK...IDVLQAEVAAL...KTLVLSSS...P...T.S.P...Tqep..
  16 A.QGK...IDVLQAEVAAL...KTLVLSSS...P...T.S.P...Tqep..
  17 A.QGK...IDVLQAEVAAL...KTLVLSSS...P...T.S.P...Tqep..
  18 A.QGK...IDVLQAEVAAL...KTLVLSSS...P...T.S.P...Tqep..
  19 A.QGK...IDVLQAEVAAL...KTLVLSSS...P...T.S.P...Tqep..
  20 A.QGK...IDVLQAEVAAL...KTLVLSSS...P...T.S.P...Tqep..
  21 A.QGK...IDVLQAEVAAL...KTLVLSSS...P...T.S.P...Tqep..
  22 A.QGK...IDVLQAEVAAL...KTLVLSSS...P...T.S.P...Tqep..
  23 A.QGK...IDVLQAEVAAL...KTLVLSSS...P...T.S.P...Tqep..
  24 A.QGK...IDVLQAEVAAL...KTLVLSSS...P...T.S.P...Tqep..
  25 A.QGK...IDVLQAEVAAL...KTLVLSSS...P...T.S.P...Tqep..
  26 A.QGK...IDVLQAEVAAL...KTLVLSSS...P...T.S.P...Tqep..
  27 A.QGK...IDVLQAEVAAL...KTLVLSSS...P...T.S.P...Tqep..
  28 T.ESL...LASHQEQLAEL...KSVLQVMN...I...SkD.D...Ldg...
  29 A.QGK...IDVLQAEVAAL...KTLVLSSS...P...T.S.P...Tqep..
  30 A.QGK...IDVLQAEVAAL...KTLVLSSS...P...T.S.P...Tqep..
  31 T.EIL...LKLQNDQLAEL...KAVMEQMH...V...D.R.E...Dqna..
  32 T.EGI...MLEQQRVLADL...QRQVEKLQ...S...G.S.S...Mksn..
  33 K.NII...INDLQEQLQDL...KQMFIKME...E...Q.S.K...Iqsy..
  34 K.NII...INDLQEQLQDL...KQMFIKME...E...Q.S.K...Iqsy..
  35 T.EGI...MLEQQKVLADL...QHQVEKLQ...I...S.G.S...Rkdg..
  36 A.EVL...QHSLQEQLQDL...KGVVEKMS...I...H.G.D...Dses..
  37 K.DLL...LDTLSMQLKNL...KNVLYKFE...N...D.F.N...Sskn..
  38 K.DTV...LETLNLQLKNL...KKVLQTVD...S...E.S.S...Inan..
  39 A.ETL...LSSTQHQLTEL...KDVMHSMS...D...S.H.E...Qnna..
  40 K.NTI...IDNLQDQLKDL...KQLFFRIE...E...Q.H.K...Ltfs..
  41 K.DML...LDTLTIQLKNL...KDVLYKVE...D...E.Q.N...Trsr..
  42 K.DXL...LDTLTLQLKNL...KKVMHS--...-...-.-.-...-.....
  43 A.LGK...IDVLQAEVAAL...KTLVLSTS...P...T.S.P...Ckem..
  44 A.QG-...-----------...--------...-...-.-.-...-.....
  45 K.QTI...IDDLQEQLKDL...KILFIRID...N...Q.Q.R...Lfan..
  46 A.EEA...VSIMQAQMQALqaeK-------...-...-.-.-...-.....
  47 A.EAV...VQAMQVQLQSL...-SVVTSGDka.L...S.G.P...Fl....
  48 R.DNL...LESLQAQLSAL...KQAMQERD...E...E.E.D...Rlqn..
  49 K.RKR...LERLEKAMERV...ERLRAL--...-...-.-.-...-.....
  50 K.RKR...LDRLEKAMERV...ERLRGLVG...-...-.-.-...-.....
  51 K.RAR...LERLEKAMARV...ERIRAM--...-...-.-.-...-.....
  52 K.RTR...LERLEKAMERV...ERIRAL--...-...-.-.-...-.....
  53 K.RRR...LEKLEGAMSRI...ERVRLMLA...Ea..E.Q.D...Vesskq
  54 K.RKR...LDRLEKAMERV...ERLRAL--...-...-.-.-...-.....
  55 K.RNR...LERLEKAMERV...ERIRAL--...-...-.-.-...-.....
  56 K.MAR...LDRLEKAVSRI...DRVKAILN...Qpq.T.N.G...Vaagg.
  57 KvEQ-...-----------...--------...-...-.-.-...-.....
  58 K.KRR...LERLELAVGRI...ERVKKLLE...E...S.-.-...-.....
  59 K.EALqsaLRLLDDQTR--...--------...-...-.-.-...-.....
  60 K.RRR...LERLERAVGRI...ERVRGVLG...E...L.E.G...Leg6gd
  61 K.KER...LEMLEGAVRRM...ERVRDVLK...E...T.S.Q...Vm10ee
  62 K.KER...LEMLEGAVRRM...ERVRDVLK...E...T.S.Q...Vm10ee